Machine intelligence
Google is at the forefront of innovation in Machine Intelligence, with active research exploring virtually all aspects of machine learning, including deep learning and more classical algorithms. Exploring theory as well as application, much of our work on language, speech, translation, visual processing, ranking and prediction relies on Machine Intelligence. In all of those tasks and many others, we gather large volumes of direct or indirect evidence of relationships of interest, applying learning algorithms to understand and generalize.
Machine Intelligence at Google raises deep scientific and engineering challenges, allowing us to contribute to the broader academic research community through technical talks and publications in major conferences and journals. Contrary to much of current theory and practice, the statistics of the data we observe shifts rapidly, the features of interest change as well, and the volume of data often requires enormous computation capacity. When learning systems are placed at the core of interactive services in a fast changing and sometimes adversarial environment, combinations of techniques including deep learning and statistical models need to be combined with ideas from control and game theory.
Recent Publications
Aptamers as a sandbox for lab-in-the-loop agentic molecular discovery
Zach Cutts
John Coller
Rachel Chen
Hua Tang
Ryder Easterlin
Dina Zverinski
Petar Sirkovic
arXiv preprint arXiv:2610.24806 (2026)
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Despite breakthroughs in AI-driven molecular generation, existing discovery pipelines operate largely in silico, with wet-lab feedback reserved for validation rather than iterative improvement. Whether large language model (LLM)-based reasoning agents can accelerate de novo discovery by iterating with lab data remains unproven.
Here we use protein-binding aptamer design as a sandbox (1-2 week cycles, $1-$3 per candidate) to demonstrate a wet lab in a closed loop with AI systems. We tasked agentic pipelines with developing aptamer binders against α-thrombin and myoglobin across three design-test-improve cycles (∼1,000 candidates per round; ∼4,400 constructs). Statistically significant, bead-corrected on-target hit rates among new candidates rose across rounds from 0.0% in Round 1 to 26.0% in Round 2 and 42.1% in Round 3 on α-thrombin (37.1% excluding literature motif descendants), and from 10.2% in Round 1 to 3.7% in Round 2 and 33.5% in Round 3 on myoglobin. Single-clone bead-binding titrations of eight full-length α-thrombin candidates confirmed concordance with pooled sequencing enrichment (Pearson r=0.90). In these assays, literature-derived motifs engineered by the agents to reduce off-target reactivity in the pooled screen reached apparent affinities of KD=24.6--133 nM, whereas de novo scaffolds showed low-micromolar binding (KD>1 μM).
We also report how our pipelines used myoglobin binding data to exploit the G-quadruplex binder space, diagnose cross-reactivity as on-target specificity dropped from 75.0% to 19.1%, and recover by developing strategies that restored specificity to 72.4%. We demonstrate that empirical lab data is more valuable than existing computational proxies, showing how iterative experimental feedback enables AI agents to diagnose assay artifacts and refine molecular designs across rounds.
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The Ontic-Epistemic Distinction: Implications for General Intelligence
Master's Thesis (2026) (to appear)
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The current pursuit of robust machine intelligence is largely predicated on a substrate independent, computational functionalist view of cognition, where sufficiently complex computational processing is expected to eventually yield generalized reasoning. This paper explores the ontological distinctions between these computational frameworks and biological cognition, specifically how these differences impact the capacity for semantic understanding. By analyzing phenomena such as the "reversal curse" where models fail to generalize the symmetry in identity relations (A=B implies B=A), and performance on novel reasoning benchmarks (e.g., ARC-AGI), this paper examines whether current model limitations are transient artifacts of scale or indicative of a distinct architectural category. Integrating Stevan Harnad’s “symbol grounding problem” with Evan Thompson’s biological model of “intrinsic normativity,” I investigate whether robust general intelligence might require sense-making: a process distinct from information processing, whereby an agent’s internal states are causally coupled with its environment via survival or system-wide stakes which grounds symbols in meaning. Current Large Language Models (LLMs) appear to lack this intrinsic normativity, and consequently may operate primarily as epistemic instruments rather than ontic agents. By introducing the concept of “ontic grounding”, this paper presents a potential framework for distinguishing between the simulation of reasoning and true understanding, which could have implications for AI safety and governance.
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Approaching the Privacy-Enhancing Technologies Adoption from a Requirements Engineering Perspective
Oleksandr Kosenkov
Danica Vranjanin
Abhinava Singh
Vadym Honcharenko
Volodymyr Spirin
2026
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In recent decades, Privacy Enhancing Technologies (PETs) have been gaining attention as a means to fulfill regulatory and user privacy requirements when processing personal data in software systems. Despite broad attention in research, support by regulators, contributions and adoption by large technological companies (like Google or Microsoft), and interest from software developers, adoption of PETs in practice is still challenging and lagging. For many years, existing research points to the same typical challenges to the adoption of PETs, such as complexity or absence of training; however, these challenges remain unresolved in practice despite the recent efforts.
In this industrial challenge paper, we take a deeper, practical requirements engineering-driven perspective on the challenges to PETs adoption across different stakeholders (namely, PETs developers and integrators, and PET adopters and users) and different disciplines (engineering, law, and business).
We suggest that the adoption of PETs should be facilitated with an in-depth understanding of engineering, business, and legal challenges to PETs, such as PETs' impact on software architecture, their business impact, and contribution to compliance. We suggest that requirements engineering research can play a crucial role in better exploring and modeling such viewpoints. In practice, requirements engineering could facilitate the coordination of the involved viewpoints to enable the adoption of existing and the development of new PETs.
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Claim-Gated Source-Risk Auditing for Generative Search
Chuhong Xu
Mark Zhou
Iris Qian
Zhaoyi Li
2026
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Generative search can cite a passage accurately
while omitting a material relationship that changes how the
passage should be interpreted. This paper introduces an original
methodological framework and implementation blueprint for
auditing that gap; it is not an AI detector, classifier, or empirical
performance study. The framework combines a five-dimensional
query–source–answer record, an operational source-role taxonomy,
a derived omission endpoint, and explicit rules for uncertainty
and human review. Its central contribution is a claim-gated
evaluation protocol specifying the sampling, evidence capture,
blinded annotation, adjudication, agreement, accuracy, calibration,
error analysis, and paired intervention tests required before
detector, prevalence, or defense-effect claims are admissible. A
1,000-row synthetic workbook serves only as a specification fixture
for testing serialization and machine-checkable invariants. Its
score vectors are normalized within 5 × 10−4
and its recorded
labels match their vector argmax, but it lacks the provenance and
independent labels required for semantic validation. We therefore
make no claim about Web prevalence, detector accuracy, or
deployment benefit. The result is an implementation-oriented
audit methodology with falsifiable evidence gates for future realWeb evaluation.
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Towards conversational artificial intelligence for disease management
Khaled Saab
David Stutz
Yong Cheng
Kavita Kulkarni
Sara Mahdavi
Joelle Barral
James Manyika
Ryutaro Tanno
Adam Rodman
Nature (2026)
Preview abstract
Although large language models have shown promise in diagnostic dialogue, their capabilities for effective management reasoning, including disease progression, therapeutic response and safe medication prescription, have remained underexplored. We have advanced the previously demonstrated diagnostic capabilities of the Articulate Medical Intelligence Explorer (AMIE) using a new large-language-model-based agentic system optimized for multivisit clinical management and dialogue. To ground the reasoning of AMIE in authoritative clinical knowledge, we leveraged the long-context capabilities of Gemini, combining in-context retrieval with structured reasoning to align its output with up-to-date clinical practice guidelines and drug formularies. In a randomized, blinded virtual Objective Structured Clinical Examination study, AMIE was compared to 21 primary care physicians (PCPs) across 100 multivisit case scenarios designed to reflect the guidance of the UK National Institute for Health and Care Excellence and BMJ Best Practice guidelines. AMIE was non-inferior to PCPs in management reasoning, as assessed by specialists, and scored better both with respect to preciseness of treatment and investigation, and in terms of its alignment with and grounding in clinical guidelines. To benchmark medication reasoning, we developed RxQA, a multiple-choice question benchmark that was derived from two national drug formularies (from the USA and UK) and validated by board-certified pharmacists. Although AMIE and PCPs both benefited from the ability to access external drug information, AMIE outperformed PCPs on higher-difficulty questions. Although further research will be needed before real-world translation of AMIE, its strong performance across evaluations marks a significant step towards use of conversational artificial intelligence as a tool in disease management.
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The field of Human-Computer Interaction is approaching a critical inflection point, moving beyond the era of static, deterministic systems into a new age of self-evolving systems. We introduce the concept of Adaptive generative interfaces that move beyond static artifacts to autonomously expand their own feature sets at runtime. Rather than relying on fixed layouts, these systems utilize generative methods to morph and grow in real-time based on a user’s immediate intent. The system operates through three core mechanisms: Directed synthesis (generating new features from direct commands), Inferred synthesis (generating new features for unmet needs via inferred commands), and Real-time adaptation (dynamically restructuring the interface's visual and functional properties at runtime). To empirically validate this paradigm, we executed a within-subject (repeated measures) comparative study (N=72) utilizing 'Penny,' a digital banking prototype. The experimental design employed a counterbalanced Latin Square approach to mitigate order effects, such as learning bias and fatigue, while comparing Deterministic interfaces baseline against an Adaptive generative interfaces. Participant performance was verified through objective screen-capture evidence, with perceived usability quantified using the industry-standard System Usability Scale (SUS). The results demonstrated a profound shift in user experience: the Adaptive generative version achieved a System Usability Scale (SUS) score of 84.38 ('Excellent'), significantly outperforming the Deterministic version’s score of 53.96 ('Poor'). With a statistically significant mean difference of 30.42 points (p < 0.0001) and a large effect size (d=1.04), these findings confirm that reducing 'navigation tax' through adaptive generative interfaces directly correlates with a substantial increase in perceived usability. We conclude that deterministic interfaces are no longer sufficient to manage the complexity of modern workflows. The future of software lies not in a fixed set of pre-shipped features, but in dynamic capability sets that grow, adapt, and restructure themselves in real-time to meet the specific intent of the user. This paradigm shift necessitates a fundamental transformation in product development, requiring designers to transcend traditional, linear workflows and evolve into 'System Builders'—architects of the design principles and rules that facilitate this new age of self-evolving software.
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