Machine intelligence
Google is at the forefront of innovation in Machine Intelligence, with active research exploring virtually all aspects of machine learning, including deep learning and more classical algorithms. Exploring theory as well as application, much of our work on language, speech, translation, visual processing, ranking and prediction relies on Machine Intelligence. In all of those tasks and many others, we gather large volumes of direct or indirect evidence of relationships of interest, applying learning algorithms to understand and generalize.
Machine Intelligence at Google raises deep scientific and engineering challenges, allowing us to contribute to the broader academic research community through technical talks and publications in major conferences and journals. Contrary to much of current theory and practice, the statistics of the data we observe shifts rapidly, the features of interest change as well, and the volume of data often requires enormous computation capacity. When learning systems are placed at the core of interactive services in a fast changing and sometimes adversarial environment, combinations of techniques including deep learning and statistical models need to be combined with ideas from control and game theory.
Recent Publications
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The field of Human-Computer Interaction is approaching a critical inflection point, moving beyond the era of static, deterministic systems into a new age of self-evolving systems. We introduce the concept of Adaptive generative interfaces that move beyond static artifacts to autonomously expand their own feature sets at runtime. Rather than relying on fixed layouts, these systems utilize generative methods to morph and grow in real-time based on a user’s immediate intent. The system operates through three core mechanisms: Directed synthesis (generating new features from direct commands), Inferred synthesis (generating new features for unmet needs via inferred commands), and Real-time adaptation (dynamically restructuring the interface's visual and functional properties at runtime). To empirically validate this paradigm, we executed a within-subject (repeated measures) comparative study (N=72) utilizing 'Penny,' a digital banking prototype. The experimental design employed a counterbalanced Latin Square approach to mitigate order effects, such as learning bias and fatigue, while comparing Deterministic interfaces baseline against an Adaptive generative interfaces. Participant performance was verified through objective screen-capture evidence, with perceived usability quantified using the industry-standard System Usability Scale (SUS). The results demonstrated a profound shift in user experience: the Adaptive generative version achieved a System Usability Scale (SUS) score of 84.38 ('Excellent'), significantly outperforming the Deterministic version’s score of 53.96 ('Poor'). With a statistically significant mean difference of 30.42 points (p < 0.0001) and a large effect size (d=1.04), these findings confirm that reducing 'navigation tax' through adaptive generative interfaces directly correlates with a substantial increase in perceived usability. We conclude that deterministic interfaces are no longer sufficient to manage the complexity of modern workflows. The future of software lies not in a fixed set of pre-shipped features, but in dynamic capability sets that grow, adapt, and restructure themselves in real-time to meet the specific intent of the user. This paradigm shift necessitates a fundamental transformation in product development, requiring designers to transcend traditional, linear workflows and evolve into 'System Builders'—architects of the design principles and rules that facilitate this new age of self-evolving software.
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XProf: An Open, Scalable and Extensible Profiling System for the Modern ML Stack
Naveen Kumar
Jose Baiocchi Paredes
Scott Goodson
Kelvin Le
Yin Zhang
Kan Cai
Jiten Thakkar
Sai Ganesh Bandiatmakuri
Yogesh SY
Ani Udipi
Vikas Aggarwal
Ninth Conference on Machine Learning and Systems (2026)
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Optimizing Large Models across thousands of accelerators requires deep system expertise. To address modern machine learning (ML) optimization needs, we present XProf, the ML profiler for the OpenXLA ecosystem. XProf delivers actionable optimization suggestions and in-depth performance analysis, empowering ML researchers and framework users to improve efficiency without specialized systems knowledge. XProf provides a unified, full-stack view of both host (CPU) and device (accelerator - TPUs/GPUs) performance, leveraging tools like the Roofline Model for comprehensive analysis. XProf’s distributed architecture is designed to monitor thousands of chips with minimal workload overhead (<1%). This architecture is made pluggable through the open-source PJRT C API extension, which has facilitated its adoption by third-party accelerator vendors. XProf has been instrumental in achieving significant efficiency gains at Google and winning MLPerf submissions. This paper presents the design and architecture of XProf, showcases its differentiating tools and capabilities, and highlights its impact within Google and across the industry as a state of the art ML profiler. XProf is available as part of the OpenXLA project at https://github.com/openxla/xprof.
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Towards Conversational AI for Disease Management
Khaled Saab
David Stutz
Yong Cheng
Kavita Kulkarni
Sara Mahdavi
Joelle Barral
James Manyika
Ryutaro Tanno
Adam Rodman
Nature (2026)
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While large language models (LLMs) have shown promise in diagnostic dialogue, their capabilities for effective management reasoning - including disease progression, therapeutic response, and safe medication prescription - remain under-explored. We advance the previously demonstrated diagnostic capabilities of the Articulate Medical Intelligence Explorer (AMIE) through a new LLM-based agentic system optimised for clinical management and dialogue, incorporating reasoning over the evolution of disease and multiple patient visit encounters, response to therapy, and professional competence in medication prescription. To ground its reasoning in authoritative clinical knowledge, AMIE leverages Gemini's long-context capabilities, combining in-context retrieval with structured reasoning to align its output with relevant and up-to-date clinical practice guidelines and drug formularies. In a randomized, blinded virtual Objective Structured Clinical Examination (OSCE) study, AMIE was compared to 21 primary care physicians (PCPs) across 100 multi-visit case scenarios designed to reflect UK NICE Guidance and BMJ Best Practice guidelines. AMIE was non-inferior to PCPs in management reasoning as assessed by specialist physicians and scored better in both preciseness of treatments and investigations, and in its alignment with and grounding of management plans in clinical guidelines. To benchmark medication reasoning, we developed RxQA, a multiple-choice question benchmark derived from two national drug formularies (US, UK) and validated by board-certified pharmacists. While AMIE and PCPs both benefited from the ability to access external drug information, AMIE outperformed PCPs on higher difficulty questions. While further research would be needed before real-world translation, AMIE's strong performance across evaluations marks a significant step towards conversational AI as a tool in disease management.
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Multi-Agent Design: Optimizing Agents with Better Prompts and Topologies
Han Zhou
Shariq Iqbal
Ivan Vulić
Anna Korhonen
International Conference on Learning Representations (ICLR) (2026)
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Large language models (LLMs), employed as multiple agents that interact and collaborate with each other, have excelled at solving complex tasks. The agents are programmed with {prompts} that declare their functionality, along with the {workflows} that orchestrate interactions within a structured flow. Designing prompts and workflows for multi-agent systems is inherently complex, especially when addressing a new task. It often demands expert-level knowledge and involves significant trial and error. Gaining a deep understanding of the factors that contribute to effective multi-agent systems is essential for automating the entire process. Motivated by this, we first conduct an in-depth analysis of the design spaces for multi-agent systems, focusing on the impact of prompts, scaling the number of agents, and common types of agentic modules. Our findings reveal that top-performing systems often emerge from simpler design spaces, where prompts play a critical role in enhancing agent functionality and enabling more effective scaling. Based on the insights, we propose Multi-Agent System Search (MASS), a multi-stage optimization framework that performs the optimization in a pruned design space, with prompts and an influential subset of modules. We show that MASS-optimized multi-agent systems outperform existing alterntives by a substantial margin. Based on the MASS-found systems, we finally propose design principles behind building effective multi-agent systems.
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Validating conversational artificial intelligence (AI) for regulated medical software applications may present challenges, as static test datasets and manual review may be limited in identifying emergent, conversational anomalies. A multi-agent AI system may be configured in a closed-loop for automated validation. The system can, for example, utilize an end user persona simulator agent to generate prompts for a target model and a domain /regulatory expert adjudicator agent to evaluate the target model’s responses against a configurable rubric. A meta-analysis agent can analyze anomalies to identify underlying vulnerabilities, which may then be used to programmatically synthesize new adversarial personas. This adaptive process can generate evidence to support regulatory compliance and continuous performance monitoring for medical software algorithms systems.
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Large Language Models utilizing reasoning techniques improve task performance but incur significant latency and token costs due to verbose generation. Existing automatic prompt optimization(APO) frameworks target task accuracy exclusively at the expense of generating long reasoning traces. We propose Cost-Regularized Optimization of Prompts (CROP), an APO method that introduces regularization on response length by generating textual feedback in addition to standard accuracy feedback. This forces the optimization process to produce prompts that elicit concise responses containing only critical information and reasoning. We evaluate our approach on complex reasoning datasets, specifically GSM8K, LogiQA and BIG-Bench Hard. We achieved an 80.6% reduction in token consumption while maintaining competitive accuracy, seeing only a nominal decline in performance. This presents a pragmatic solution for deploying token-efficient and cost-effective agentic AI systems in production pipelines.
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