General Science

As rates of new COVID-19 cases decline across Europe due to non-pharmaceutical interventions such as social distancing policies and lockdown measures, countries require guidance on how to ease restrictions while minimizing the risk of resurgent outbreaks. Here, we use mobility and case data to quantify how coordinated exit strategies could delay continental resurgence and limit community...

Machine learning (ML) models trained to predict ligand binding to single proteins have achieved remarkable success, but cannot make predictions about protein targets other than the one they are trained on. Models that make predictions for multiple proteins and multiple ligands, known as drug-target interaction (DTI) models, aim to solve this problem but generally have lower performance. In this...

DNS operators, in particular Root Server Operators (RSOs), are periodically requested to collect query data and submit it to a central storage location where it is accessible for future research. The typical example is the yearly Day In The Life of the Internet (DITL) collections undertaken by the DNS Operations Analysis and Research Center (DNS-OARC). Some operators are uncomfortable sharing...

Some DNS recursive resolvers have longer-than-desired round-trip times to the closest DNS root server; those resolvers may have difficulty getting responses from the root servers, such as during a network attack. Some DNS recursive resolver operators want to prevent snooping by third parties of requests sent to DNS root servers. In both cases, resolvers can greatly decrease the round- trip time...