General Science

Some DNS recursive resolvers have longer-than-desired round-trip times to the closest DNS root server; those resolvers may have difficulty getting responses from the root servers, such as during a network attack. Some DNS recursive resolver operators want to prevent snooping by third parties of requests sent to DNS root servers. In both cases, resolvers can greatly decrease the round- trip time...

DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value. We demonstrate a new approach applying machine learning to DEL selection data by identifying active molecules from large libraries of commercial and easily synthesizable compounds. We train models using only DEL selection data and apply automated or...

In recent years, Deep Learning techniques have shown dramatic promise in many domains, including the geosciences. We continue this trend by investigating the application of Deep Learning techniques to the problem of \emph{precipitation nowcasting], i.e., the short-term prediction of precipitation at high spatial resolution. We treat forecasting as a image-to-image translation problem, and...

Advances in automation and imaging have made it possible to capture large imagedatasets for experiments that span multiple weeks (i.e. batches). However, almostall images experience batch-to-batch variation due to uncontrollable noise (e.g.different stain intensity or illumination conditions), and such complication makesit difficult to make biological comparison across all of the conditions...