General Science
We aim to transform scientific research itself. Many scientific endeavors can benefit from large scale experimentation, data gathering, and machine learning (including deep learning). We aim to accelerate scientific research by applying Google’s computational power and techniques in areas such as drug discovery, biological pathway modeling, microscopy, medical diagnostics, material science, and agriculture. We collaborate closely with world-class research partners to help solve important problems with large scientific or humanitarian benefit.
Recent Publications
Expert evaluation of LLM world models: A high-Tc superconductivity case study
Haoyu Guo
Maria Tikhanovskaya
Paul Raccuglia
Alexey Vlaskin
Chris Co
Scott Ellsworth
Matthew Abraham
Lizzie Dorfman
Peter Armitage
Chunhan Feng
Antoine Georges
Olivier Gingras
Dominik Kiese
Steve Kivelson
Vadim Oganesyan
Brad Ramshaw
Subir Sachdev
Senthil Todadri
John Tranquada
Eun-Ah Kim
Proceedings of the National Academy of Sciences (2026)
Preview abstract
Large Language Models (LLMs) show great promise as a powerful tool for scientific literature exploration. However, their effectiveness in providing scientifically accurate and comprehensive answers to complex questions within specialized domains remains an active area of research. This work evaluates the performance of six different LLM-based systems for answering scientific literature questions, including commercially available closed models and a custom retrieval-augmented generation (RAG) system capable of retrieving images alongside text. We conduct a rigorous expert evaluation of the systems in the domain of high-temperature cuprate superconductors, a research area that involves material science, experimental physics, computation, and theoretical physics. We use an expert-curated database of 1726 scientific papers and a set of 67 expert-formulated questions. The evaluation employs a multi-faceted rubric assessing balanced perspectives, factual comprehensiveness, succinctness, evidentiary support, and image relevance. Our results demonstrate that RAG-based systems, powered by curated data and multimodal retrieval, outperform existing closed models across key metrics, particularly in providing comprehensive and well-supported answers, and in retrieving relevant visual information. This study provides valuable insights into designing and evaluating specialized scientific literature understanding systems, particularly with expert involvement, while also highlighting the importance of rich, domain-specific data in such systems.
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Neural general circulation models for modeling precipitation
Stephan Hoyer
Dmitrii Kochkov
Janni Yuval
Ian Langmore
Science Advances (2026)
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Climate models struggle to accurately simulate precipitation, particularly extremes and the diurnal cycle. While hybrid models combining machine learning and physics have emerged with the premise of improving precipitation simulations, none have proven sufficiently skillful or stable enough to outperform existing models in simulating precipitation.
Here, we present the first hybrid model that is trained directly on precipitation observations. The model runs at 2.8 degrees resolution and is built on the differentiable NeuralGCM framework. This model is stable for decadal simulations and demonstrates significant improvements over existing GCMs, ERA5 reanalysis, and a Global Cloud-Resolving Model in simulating precipitation. Our approach yields reduced biases, a more realistic precipitation distribution, improved representation of extremes, and a more accurate diurnal cycle.
Furthermore, it outperforms the ECMWF ensemble for mid-range weather forecasting.
This advance paves the way for more reliable simulations of current climate and for the ability to fully utilize the abundance of existing observations to further improve GCMs.
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Simulation-Based Inference: A Practical Guide
Michael Deistler
Jan Boelts
Peter Steinbach
Guy Moss
Thomas Moreau
Manuel Gloeckler
Pedro L. C. Rodriguez
Julia Linhart
Janne K. Lappalainen
Benjamin Kurt Miller
Pedro J. Goncalves
Cornelius Schröder
Jakob H. Macke
arXiv (2025)
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A central challenge in many areas of science and engineering is to identify model parameters that are consistent with empirical data and prior knowledge. Bayesian inference offers a principled framework for this task, but can be computationally prohibitive when models are defined by stochastic simulators. Simulation-Based Inference (SBI) provides a suite of methods to overcome this limitation and has enabled scientific discoveries in fields such as particle physics, astrophysics and neuroscience. The core idea of SBI is to train neural networks on data generated by a simulator, without requiring access to likelihood evaluations. Once trained, the neural network can rapidly perform inference on empirical observations without requiring additional optimization or simulations. In this tutorial, we provide a practical guide for practitioners aiming to apply SBI methods. We outline a structured SBI workflow and offer practical guidelines and diagnostic tools for every stage of the process--from setting up the simulator and prior, choosing the SBI method and neural network architecture, training the inference model, to validating results and interpreting the inferred parameters. We illustrate these steps through examples from astrophysics, psychophysics, and neuroscience. This tutorial empowers researchers to apply state-of-the-art SBI methods, facilitating efficient parameter inference for scientific discovery.
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Preview abstract
The need for characterizing global variability of atmospheric carbon dioxide (CO2) is quickly increasing, with a growing urgency for tracking greenhouse gasses with sufficient resolution, precision and accuracy so as to support independent verification of CO2 fluxes at local to global scales. The current generation of space-based sensors, however, can only provide sparse observations in space and/or in time, by design. While upcoming missions may address some of these challenges, most are still years away from launch. This challenge has fueled interest in the potential use of data from existing missions originally developed for other applications for inferring global greenhouse gas variability.
The Advanced Baseline Imager (ABI) onboard the Geostationary Operational Environmental Satellite (GOES-East), operational since 2017, provides full coverage of much of the western hemisphere at 10-minute intervals from geostationary orbit at 16 wavelengths. We leverage this high temporal resolution by developing a single-pixel, fully-connected neural network to estimate dry-air column CO2 mole fractions (XCO2). The model employs a time series of GOES-East's 16 spectral bands, which aids in disentangling atmospheric CO2 from surface reflectance, alongside ECMWF ERA5 lower tropospheric meteorology, solar angles, and day of year. Training used collocated GOES-East and OCO-2/OCO-3 observations (2017-2020, within 5 km and 10 minutes), with validation and testing performed on 2021 data.
The model successfully captures monthly latitudinal XCO2 gradients and shows reasonable agreement with ground-based TCCON measurements. Furthermore, we demonstrate the model's ability to detect elevated XCO2 signals from high-emitting power plants, particularly over low-reflectance surfaces. We also confirm that removing bands 5 (1.6 µm) and 16 (13.3 µm) substantially decreases performance, indicating that the model is able to extract useful information from these bands.
Although GOES-East derived XCO2 precision may not rival dedicated instruments, its unprecedented combination of contiguous geographic coverage, 10-minute temporal frequency, and multi-year record offers the potential to observe aspects of atmospheric CO2 variability currently unseen from space, with further potential through spatio-temporal aggregation.
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Gemini & Physical World: Large Language Models Can Estimate the Intensity of Earthquake Shaking from Multi-Modal Social Media Posts
Marc Stogaitis
Tajinder Gadh
Richard Allen
Alexei Barski
Robert Bosch
Patrick Robertson
Youngmin Cho
Nivetha Thiruverahan
Aman Raj
Geophysical Journal International (2025), ggae436
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This paper presents a novel approach for estimating the ground shaking intensity using real-time social media data and CCTV footage. Employing the Gemini 1.5 Pro’s (Reid et al. 2024) model, a multi-modal language model, we demonstrate the ability to extract relevant information from unstructured data utilizing generative AI and natural language processing. The model’s output, in the form of Modified Mercalli Intensity (MMI) values, align well with independent observational data. Furthermore, our results suggest that beyond its advanced visual and auditory understanding abilities, Gemini appears to utilize additional sources of knowledge, including a simplified understanding of the general relationship between earthquake magnitude, distance, and MMI intensity, which it presumably acquired during its training, in its reasoning and decision-making processes. These findings raise intriguing questions about the extent of Gemini's general understanding of the physical world and its phenomena. Gemini’s ability to generate results consistent with established scientific knowledge highlights the potential of LLMs like Gemini in augmenting our understanding of complex physical phenomena such as earthquakes. More specifically, the results of this study highlight the potential of LLMs like Gemini to revolutionize citizen seismology by enabling rapid, effective, and flexible analysis of crowdsourced data from eyewitness accounts for assessing earthquake impact and providing crisis situational awareness. This approach holds a great promise for improving early warning systems, disaster response, and overall resilience in earthquake-prone regions. This study provides a significant step toward harnessing the power of social media and AI for earthquake disaster mitigation.
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Towards AI-assisted academic writing
Malcolm Kane
Madeleine Grunde-McLaughlin
Ian Lang
Proceedings of the 1st Workshop on AI and Scientific Discovery: Directions and Opportunities, Association for Computational Linguistics (2025), pp. 31-45
Preview abstract
We present components of an AI-assisted academic writing system including citation recommendation and introduction writing. The system recommends citations by considering the user’s current document context to provide relevant suggestions. It generates introductions in a structured fashion, situating the contributions of the research relative to prior work. We demonstrate the effectiveness of the components through quantitative evaluations. Finally, the paper presents qualitative research exploring how researchers incorporate citations into their writing workflows. Our findings indicate that there is demand for precise AI-assisted writing systems and simple, effective methods for meeting those needs.
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