Blaise Aguera y Arcas
Blaise Agüera y Arcas is a VP and Fellow at Google, where he is the CTO of Technology & Society and founder of Paradigms of Intelligence (Pi). Pi is an organization working on basic research in AI and related fields, especially the foundations of neural computing, active inference, sociality, evolution, and Artificial Life.
In 2008, Blaise was awarded MIT’s TR35 prize. During his tenure at Google, Blaise has innovated on-device machine learning for Android and Pixel; invented Federated Learning, an approach to decentralized model training that avoids sharing private data; and founded the Artists + Machine Intelligence program.
Prior to Google, Blaise was a Distinguished Engineer at Microsoft, where he worked in a variety of roles, from inventor to strategist, and led teams with strengths in experience design, prototyping, machine vision, augmented reality, wearable computing and mapping.
Authored Publications
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LLMs achieve adult human performance on higher-order theory of mind tasks
Oliver Siy
Geoff Keeling
Benjamin Barnett
Michael McKibben
Tatenda Kanyere
Robin I.M. Dunbar
Frontiers in Human Neuroscience (2025)
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This paper examines the extent to which large language models (LLMs) are able to perform tasks which require higher-order theory of mind (ToM)–the human ability to reason about multiple mental and emotional states in a recursive manner (e.g. I think that you believe that she knows). This paper builds on prior work by introducing a handwritten test suite – Multi-Order Theory of Mind Q&A – and using it to compare the performance of five LLMs of varying sizes and training paradigms to a newly gathered adult human benchmark. We find that GPT-4 and Flan-PaLM reach adult-level and near adult-level performance on our ToM tasks overall, and that GPT-4 exceeds adult performance on 6th order inferences. Our results suggest that there is an interplay between model size and finetuning for higher-order ToM performance, and that the linguistic abilities of large models may support more complex ToM inferences. Given the important role that higher-order ToM plays in group social interaction and relationships, these findings have significant implications for the development of a broad range of social, educational and assistive LLM applications.
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Towards Generalist Biomedical AI
Danny Driess
Andrew Carroll
Chuck Lau
Ryutaro Tanno
Ira Ktena
Basil Mustafa
Aakanksha Chowdhery
Simon Kornblith
Philip Mansfield
Sushant Prakash
Renee Wong
Sunny Virmani
Sara Mahdavi
Bradley Green
Ewa Dominowska
Joelle Barral
Karan Singhal
Pete Florence
NEJM AI (2024)
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BACKGROUND: Medicine is inherently multimodal, requiring the simultaneous interpretation and integration of insights between many data modalities spanning text, imaging, genomics, and more. Generalist biomedical artificial intelligence systems that flexibly encode, integrate, and interpret these data might better enable impactful applications ranging from scientific discovery to care delivery.
METHODS: To catalyze development of these models, we curated MultiMedBench, a new multimodal biomedical benchmark. MultiMedBench encompasses 14 diverse tasks, such as medical question answering, mammography and dermatology image interpretation, radiology report generation and summarization, and genomic variant calling. We then introduced Med-PaLM Multimodal (Med-PaLM M), our proof of concept for a generalist biomedical AI system that flexibly encodes and interprets biomedical data including clinical language, imaging, and genomics with the same set of model weights. To further probe the capabilities and limitations of Med-PaLM M, we conducted a radiologist evaluation of model-generated (and human) chest x-ray reports.
RESULTS: We observed encouraging performance across model scales. Med-PaLM M reached performance competitive with or exceeding the state of the art on all MultiMedBench tasks, often surpassing specialist models by a wide margin. In a side-by-side ranking on 246 retrospective chest x-rays, clinicians expressed a pairwise preference for Med-PaLM Multimodal reports over those produced by radiologists in up to 40.50% of cases, suggesting potential clinical utility.
CONCLUSIONS: Although considerable work is needed to validate these models in real-world cases and understand if cross-modality generalization is possible, our results represent a milestone toward the development of generalist biomedical artificial intelligence systems.
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Computational Life: How Well-formed, Self-replicating Programs Emerge from Simple Interaction
Luca Versari
James Evans
arxiv (2024)
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The fields of Origin of Life and Artificial Life both question what life is and how it emerges from a distinct set of "pre-life" dynamics. One common feature of most substrates where life emerges is a marked shift in dynamics when self-replication appears. While there are some hypotheses regarding how self-replicators arose in nature, we know very little about the general dynamics, computational principles, and necessary conditions for self-replicators to emerge. This is especially true on "computational substrates" where interactions involve logical, mathematical, or programming rules. In this paper we take a step towards understanding how self-replicators arise by studying several computational substrates based on various simple programming languages and machine instruction sets. We show that when random, non self-replicating programs are placed in an environment lacking any explicit fitness landscape, self-replicators tend to arise. We demonstrate how this occurs due to random interactions and self-modification, and can happen with and without background random mutations. We also show how increasingly complex dynamics continue to emerge following the rise of self-replicators. Finally, we show a counterexample of a minimalistic programming language where self-replicators are possible, but so far have not been observed to arise.
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Cascades are a common type of machine learning system where a larger, remote model can be queried if a local model is not able to handle a user’s query by itself. They are becoming an increasingly popular choice of a design for Large Language Models (LLMs) serving stacks due to their ability to preserve task performance, while dramatically reducing inference costs. However, applying cascade systems in situations where the local model has access to sensitive data constitutes a significant privacy risk for users since any such data could be forwarded to the remote model. In this work, we show the feasibility of applying cascade systems in such setups, equipping the local model with privacy-preserving techniques that reduce the risk of leaking private information when querying the remote model. To analyze the privacy of such a setup, we introduce a novel privacy measure that quantifies sensitive information leakage. We then propose a system that leverages the recently introduced social learning paradigm in which LLMs collaboratively learn from each other by exchanging natural language and demonstrate on several datasets that our methods minimize the privacy loss while at the same time improving task performance compared to a non-cascade baseline.
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Towards Physician-Level Medical Question Answering with Large Language Models
Karan Singhal
Juro Gottweis
Le Hou
Kevin Clark
Heather Cole-Lewis
Amy Wang
Sami Lachgar
Philip Mansfield
Sushant Prakash
Bradley Green
Ewa Dominowska
Nenad Tomašev
Renee Wong
Sara Mahdavi
Joelle Barral
Arxiv (2023) (to appear)
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Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge.
Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach.
Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets.
We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations.
While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.
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Large Language Models Encode Clinical Knowledge
Karan Singhal
Sara Mahdavi
Jason Wei
Hyung Won Chung
Nathan Scales
Ajay Tanwani
Heather Cole-Lewis
Perry Payne
Martin Seneviratne
Paul Gamble
Christopher Kelly
Abubakr Abdelrazig Hassan Babiker
Nathanael Schaerli
Aakanksha Chowdhery
Philip Mansfield
Dina Demner-Fushman
Katherine Chou
Juraj Gottweis
Nenad Tomašev
Alvin Rajkomar
Joelle Barral
Nature (2023)
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Large language models (LLMs) have demonstrated impressive capabilities, but the bar for clinical applications is high. Attempts to assess the clinical knowledge of models typically rely on automated evaluations based on limited benchmarks. Here, to address these limitations, we present MultiMedQA, a benchmark combining six existing medical question answering datasets spanning professional medicine, research and consumer queries and a new dataset of medical questions searched online, HealthSearchQA. We propose a human evaluation framework for model answers along multiple axes including factuality, comprehension, reasoning, possible harm and bias. In addition, we evaluate Pathways Language Model (PaLM, a 540-billion parameter LLM) and its instruction-tuned variant, Flan-PaLM on MultiMedQA. Using a combination of prompting strategies, Flan-PaLM achieves state-of-the-art accuracy on every MultiMedQA multiple-choice dataset (MedQA, MedMCQA, PubMedQA and Measuring Massive Multitask Language Understanding (MMLU) clinical topics), including 67.6% accuracy on MedQA (US Medical Licensing Exam-style questions), surpassing the prior state of the art by more than 17%. However, human evaluation reveals key gaps. To resolve this, we introduce instruction prompt tuning, a parameter-efficient approach for aligning LLMs to new domains using a few exemplars. The resulting model, Med-PaLM, performs encouragingly, but remains inferior to clinicians. We show that comprehension, knowledge recall and reasoning improve with model scale and instruction prompt tuning, suggesting the potential utility of LLMs in medicine. Our human evaluations reveal limitations of today’s models, reinforcing the importance of both evaluation frameworks and method development in creating safe, helpful LLMs for clinical applications.
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LaMDA: Language Models for Dialog Applications
Aaron Daniel Cohen
Alena Butryna
Alicia Jin
Apoorv Kulshreshtha
Ben Zevenbergen
Chung-ching Chang
Cosmo Du
Daniel De Freitas Adiwardana
Dehao Chen
Dmitry (Dima) Lepikhin
Erin Hoffman-John
Igor Krivokon
James Qin
Jamie Hall
Joe Fenton
Johnny Soraker
Kathy Meier-Hellstern
Maarten Paul Bosma
Marc Joseph Pickett
Marcelo Amorim Menegali
Marian Croak
Maxim Krikun
Rachel Bernstein
Ravi Rajakumar
Ray Kurzweil
Romal Thoppilan
Steven Zheng
Taylor Bos
Toju Duke
Tulsee Doshi
Vincent Y. Zhao
Will Rusch
Yanping Huang
Yuanzhong Xu
Zhifeng Chen
arXiv (2022)
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We present LaMDA: Language Models for Dialog Applications. LaMDA is a family of Transformer-based neural language models specialized for dialog, which have up to 137B parameters and are pre-trained on 1.56T words of public dialog data and web text. While model scaling alone can improve quality, it shows less improvements on safety and factual grounding. We demonstrate that fine-tuning with annotated data and enabling the model to consult external knowledge sources can lead to significant improvements towards the two key challenges of safety and factual grounding.The first challenge, safety, involves ensuring that the model’s responses are consistent with a set of human values, such as preventing harmful suggestions and unfair bias. We quantify safety using a metric based on an illustrative set of values, and we find that filtering candidate responses using aLaMDA classifier fine-tuned with a small amount of crowdworker-annotated data offers a promising approach to improving model safety. The second challenge, factual grounding, involves enabling the model to consult external knowledge sources, such as an information retrieval system, a language translator, and a calculator. We quantify factuality using a groundedness metric, and we find that our approach enables the model to generate responses grounded in known sources, rather than responses that merely sound plausible. Finally, we explore the use of LaMDA in the domains of education and content recommendations, and analyze their helpfulness and role consistency.
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Privacy-first Health Research with Federated Learning
Adam Sadilek
Dung Nguyen
Methun Kamruzzaman
Benjamin Rader
Stefan Mellem
Elaine O. Nsoesie
Jamie MacFarlane
Anil Vullikanti
Madhav Marathe
Paul C. Eastham
John S. Brownstein
npj Digital Medicine (2021)
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Privacy protection is paramount in conducting health research. However, studies often rely on data stored in a centralized repository, where analysis is done with full access to the sensitive underlying content. Recent advances in federated learning enable building complex machine-learned models that are trained in a distributed fashion. These techniques facilitate the calculation of research study endpoints such that private data never leaves a given device or healthcare system. We show—on a diverse set of single and multi-site health studies—that federated models can achieve similar accuracy, precision, and generalizability, and lead to the same interpretation as standard centralized statistical models while achieving considerably stronger privacy protections and without significantly raising computational costs. This work is the first to apply modern and general federated learning methods that explicitly incorporate differential privacy to clinical and epidemiological research—across a spectrum of units of federation, model architectures, complexity of learning tasks and diseases. As a result, it enables health research participants to remain in control of their data and still contribute to advancing science—aspects that used to be at odds with each other.
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A Field Guide to Federated Optimization
Jianyu Wang
Zheng Xu
Gauri Joshi
Maruan Al-Shedivat
Galen Andrew
A. Salman Avestimehr
Katharine Daly
Deepesh Data
Suhas Diggavi
Hubert Eichner
Advait Gadhikar
Antonious M. Girgis
Filip Hanzely
Chaoyang He
Samuel Horvath
Martin Jaggi
Tara Javidi
Satyen Chandrakant Kale
Sai Praneeth Karimireddy
Jakub Konečný
Sanmi Koyejo
Tian Li
Peter Richtarik
Karan Singhal
Virginia Smith
Mahdi Soltanolkotabi
Weikang Song
Sebastian Stich
Ameet Talwalkar
Hongyi Wang
Blake Woodworth
Honglin Yuan
Manzil Zaheer
Mi Zhang
Tong Zhang
Chunxiang (Jake) Zheng
Chen Zhu
arxiv (2021)
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Federated learning and analytics are a distributed approach for collaboratively learning models (or statistics) from decentralized data, motivated by and designed for privacy protection. The distributed learning process can be formulated as solving federated optimization problems, which emphasize communication efficiency, data heterogeneity, compatibility with privacy and system requirements, and other constraints that are not primary considerations in other problem settings. This paper provides recommendations and guidelines on formulating, designing, evaluating and analyzing federated optimization algorithms through concrete examples and practical implementation, with a focus on conducting effective simulations to infer real-world performance. The goal of this work is not to survey the current literature, but to inspire researchers and practitioners to design federated learning algorithms that can be used in various practical applications.
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UIBert: Learning Generic Multimodal Representations for UI Understanding
Abhinav Kumar Rastogi
Chongyang Bai
Srinivas Kumar Sunkara
Xiaoxue Zang
Ying Xu
the 30th International Joint Conference on Artificial Intelligence (IJCAI-21) (2021)
Preview abstract
To improve the accessibility of smart devices and to simplify their usage, building models which understand user interfaces (UIs) and assist users to complete their tasks is critical. However, unique challenges are proposed by UI-specific characteristics, such as how to effectively leverage multimodal UI features that involve image, text, and structural metadata and how to achieve good performance when high-quality labeled data is unavailable. To address such challenges we introduce UIBert, a transformer-based joint image-text model trained through novel pre-training tasks on large-scale unlabeled UI data to learn generic feature representations for a UI and its components. Our key intuition is that the heterogeneous features in a UI are self-aligned, i.e., the image and text features of UI components, are predictive of each other. We propose five pretraining tasks utilizing this self-alignment among different features of a UI component and across various components in the same UI. We evaluate our method on nine real-world downstream UI tasks where UIBert outperforms strong multimodal baselines by up to 9.26% accuracy.
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