Publications
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
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1 - 15 of 11416 publications
Preview abstract
Online video platforms face an exponential challenge
in detecting and mitigating the flood of AI-generated “slop”
and synthetic spam perpetuated by coordinated malicious actors.
This content is increasingly designed to exploit the limitations
of traditional media forensics, often utilizing generative AI to
produce unique, localized variations of harmful or low-quality
material at scale. Traditional content-centric moderation fails
against this coordinated, adversarial generation strategy.
This paper presents a novel, scalable detection and classifi-
cation framework designed for online video platforms (OVP) to
identify and triage clusters of coordinated accounts exhibiting
a prevalence of adversarial synthetic content. The approach
leverages a multi-faceted architecture incorporating two core
machine learning components: a robust Coordinated Bot-Net
Detector (via Account Relatedness) and a Synthetic Pattern Clas-
sifier. Crucially, we introduce an advanced AI enhancement layer
utilizing Large Language Models (LLMs), specialized via Low-
Rank Adaptation (LoRA) and Automatic Prompt Optimization
(APO), to achieve rapid, high-precision semantic understanding
of emerging synthetic spam trends.
Evaluated across a representative evaluation dataset (N =
16, 250 weekly candidate channels across six major synthetic
abuse verticals), the system demonstrates high precision (FPR <
0.05%) in identifying coordinated synthetic spam networks.
Furthermore, the LLM-driven classification achieves a 74%
automated triage routing rate, saving over 1, 100 operational
review hours per week while reducing investigation turnaround
times by up to 50% (p < 0.001). This work details a critical
system design that provides essential scalability and adversarial
resilience against sophisticated generative attacks.
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Towards Conversational AI for Disease Management
Khaled Saab
David Stutz
Yong Cheng
Kavita Kulkarni
Sara Mahdavi
Joelle Barral
James Manyika
Ryutaro Tanno
Adam Rodman
Nature (2026)
Preview abstract
While large language models (LLMs) have shown promise in diagnostic dialogue, their capabilities for effective management reasoning - including disease progression, therapeutic response, and safe medication prescription - remain under-explored. We advance the previously demonstrated diagnostic capabilities of the Articulate Medical Intelligence Explorer (AMIE) through a new LLM-based agentic system optimised for clinical management and dialogue, incorporating reasoning over the evolution of disease and multiple patient visit encounters, response to therapy, and professional competence in medication prescription. To ground its reasoning in authoritative clinical knowledge, AMIE leverages Gemini's long-context capabilities, combining in-context retrieval with structured reasoning to align its output with relevant and up-to-date clinical practice guidelines and drug formularies. In a randomized, blinded virtual Objective Structured Clinical Examination (OSCE) study, AMIE was compared to 21 primary care physicians (PCPs) across 100 multi-visit case scenarios designed to reflect UK NICE Guidance and BMJ Best Practice guidelines. AMIE was non-inferior to PCPs in management reasoning as assessed by specialist physicians and scored better in both preciseness of treatments and investigations, and in its alignment with and grounding of management plans in clinical guidelines. To benchmark medication reasoning, we developed RxQA, a multiple-choice question benchmark derived from two national drug formularies (US, UK) and validated by board-certified pharmacists. While AMIE and PCPs both benefited from the ability to access external drug information, AMIE outperformed PCPs on higher difficulty questions. While further research would be needed before real-world translation, AMIE's strong performance across evaluations marks a significant step towards conversational AI as a tool in disease management.
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A Theoretical Framework for Modular Learning of Robust Generative Models
Proceedings of the 43rd International Conference on Machine Learning (ICML 2026)
Preview abstract
Training large-scale generative models is resource-intensive and relies heavily on heuristic dataset weighting. We address two fundamental questions: Can we train Large Language Models (LLMs) modularly, combining small, domain-specific experts to match monolithic performance, and can we do so robustly for any data mixture, eliminating heuristic tuning? We present a theoretical framework for modular generative modeling where a set of pre-trained experts are combined via a gating mechanism. We define the space of normalized gating functions $\mathcal{G}_{1}$ and formulate the problem as a minimax game to find a single robust gate that minimizes divergence to the worst-case data mixture. We prove the existence of such a robust gate using Kakutani's fixed-point theorem and show that modularity acts as a strong regularizer, with generalization bounds scaling with the lightweight gate's complexity. Furthermore, we prove that this modular approach can theoretically outperform models retrained on aggregate data, with the gap characterized by the Jensen-Shannon Divergence. Finally, we introduce a scalable Stochastic Primal-Dual algorithm and a Structural Distillation method for efficient inference. Empirical results on synthetic and real-world datasets confirm that our modular architecture effectively mitigates gradient conflict and can robustly outperform monolithic baselines.
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Preview abstract
Source-to-source compilers may perform inefficiently by executing transpilation passes on scripts that do not contain the specific language features a pass is designed to transform, potentially leading to redundant processing. A compiler can analyze a script to generate a per-script feature map, for example, by identifying language features in its abstract syntax tree (AST). Before executing a transpilation pass, the compiler can check this map and may bypass the pass for that script if the specific feature targeted by the pass is not present. This feature map can also be dynamically updated throughout the compilation process as other passes transform the code. This method of conditional pass execution based on content-aware analysis may reduce redundant AST traversals, which could decrease overall compilation time and computational resource consumption.
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Preview abstract
Context: The cost of frontier large language model inference has fallen by two orders of magnitude since 2023, yet the techno-economic forces governing AI value capture remain poorly understood. No existing work provides a unified, multi-layer framework connecting hardware physics to commercial pricing to actuarial constraints.
Objectives: This survey aims to establish that Generative AI (GenAI) monetization is structurally bound by five interdependent techno-economic layers: (1) the physical constraints of
memory bandwidth and compute, (2) deflationary architectural innovations, (3) the algorithmic
economics of inference-time compute, (4) the verification economics governing outcome-based
pricing, and (5) the macro-legal realities of enterprise liability.
Methods: We conduct a Multivocal Literature Review (MLR) adapting the PRISMA protocol,
synthesizing peer-reviewed and grey literature sources—vendor documentation, SLAs, and API
pricing data (2022–2026). Two reviewers independently screened all records (Cohen’s κ ≥ 0.81
across all decision stages).
Results: We contribute four primary artifacts.
First, the Viability Inequality, an analytical
model formalizing the conditions under which outcome-based AI pricing is economically sustainable.
Second, the Billing Fallacy: aggregate cost growth is driven by Agentic Recursion,
not quadratic attention complexity.
Third, the Verifiability Bifurcation: objective task domains
enable outcome pricing, while subjective domains depend on proxy-based models.
Fourth, the
Multi-Layer Techno-Economic Taxonomy (M-TET), a unified five-layer framework mapping the
full monetization stack from silicon-anchored token pricing through actuarial risk ceilings.
Conclusion: GenAI monetization is not a commercial pricing exercise but a dynamic negotiation across hardware, algorithmic, economic, and actuarial layers. In subjective and hybrid
task domains, the binding constraint on outcome-based pricing is the cost of verification, not
generation. AI value capture depends on engineering low-cost, high-fidelity Verification Engines.
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Phoenix: Rowhammer Attacks on DDR5 with Self-Correcting Synchronization
Michele Marazzi
Kaveh Razavi
Salman Qazi
Diego Meyer
Patrick Jattke
IEEE Security & Privacy (S&P) (2026)
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This writeup defines the Hydration Proxy Pattern, a framework for building stateful conversational data systems over stateless LLM APIs. It describes a platform-agnostic approach to decoupling persistence from the AI provider through secure server-side intermediation and hybrid storage tiers. The abstract provides a blueprint for managing the "Persistence Gap" in enterprise AI integrations, detailing high-level strategies for session history management, streaming, and multi-stage semantic grounding without disclosing specific internal implementation details.
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In this paper we introduce \emph{OPO-CMDP}, the first policy optimization algorithm for stochastic Contextual Markov Decision Process (CMDPs) under general offline function approximation. We establish a high probability regret bound of
$\widetilde{O}\left(H^4\sqrt{T|S||A|\log(|\mathcal{F}||\mathcal{P}|)}\right),$
where $S$ and $A$ denote the state and action spaces, $H$ the horizon length, $T$ the number of episodes, and $\mathcal{F}, \mathcal{P}$ the function classes used to approximate the losses and dynamics, respectively. This result improves the dependence on $|S|$ and $|A|$ compared to the previously known state-of-the-art bound of \citet*{DBLP:conf/nips/QianHS24}. Our analysis introduces sophisticated confidence bounds for stochastic policies that eliminate restrictive assumptions required in prior work. Our results demonstrate that simple policy optimization over optimistic model approximations can achieve better, near-optimal regret bound for CMDPs.
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Differential Sensitivity of Impedance Plethysmography and Photoplethysmography Sensors to Temperature-Induced Peripheral Vasoconstriction
Seobin Jung
Seamus Thomson
Alexandros Pantelopoulos
Lindsey Sunden
Pete Richards
Shwetak Patel
Sam Sheng
Scientific Reports (2026)
Preview abstract
Impedance plethysmography (IPG) and photoplethysmography (PPG) are non-invasive techniques for measuring blood volume changes. This study investigated the differential responses of IPG and PPG to temperature-mediated vasoconstriction induced by localized cooling. Twenty-one participants underwent control and treatment conditions, with fake or real ice cubes applied to the forearm. Blood pressure remained stable, while heart rate decreased. PPG signal amplitude significantly decreased with cooling (p_adj = 0.004), indicating sensitivity to superficial blood flow changes. In contrast, IPG signal amplitude remained stable (p_adj = 1.0). No statistically significant differences were observed in timing-derived metrics. These findings suggest IPG is less sensitive to superficial changes in blood flow than PPG, and may be more suitable for monitoring deeper blood flow. This study provides insights into the distinct sensitivities of IPG and PPG, with implications for wearable device development and cardiovascular monitoring.
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Preview abstract
We consider a setting where we have a ground set ℳ together with real-valued set functions f₁, … , f_n, and the goal is to partition ℳ into two sets S₁,S₂ such that |f_i(S₁) - f_i(S₂)| is small for every i. Many results in discrepancy theory can be stated in this form with the functions f_i being additive. In this work, we initiate the study of the unstructured case where f_i is not assumed to be additive. We show that even without the additivity assumption, the upper bound remains at most O(√{n log n}).
Our result has implications on the fair allocation of indivisible goods. In particular, we show that a consensus halving up to O(√{n log n}) goods always exists for n agents with monotone utilities. Previously, only an O(n) bound was known for this setting.
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Preview abstract
Ideation, i. e., generating, capturing, organizing, and evaluating ideas, is foundational to creative practices; yet little is known about how blind and low vision ( BLV) creators engage in ideation. We conducted interviews with 20 BLV creators working in different domains including poetry, music production, tactile graphics, digital drawing, and mixed- media arts. Our findings reveal how participants established accessible creative workflows under social and institutional constraints, drew inspiration from diverse physical and digital sources, captured and organized ideas across text, audio, visual, and physical modalities, and evaluated their work through human and AI feedback. We discuss how ableist norms and accessibility breakdowns cascade across ideation pathways, progressively narrowing BLV individuals’ creative possibilities. Finally, we offer design considerations for building accessible ideation support tools that amplify BLV creators’ distinctive practices.
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Reasoning-Driven Synthetic Data Generation and Evaluation
Tim R. Davidson
Benoit Seguin
Transactions on Machine Learning Research (2026)
Preview abstract
Although many AI applications of interest require specialized multi-modal models, relevant data to train such models is inherently scarce or inaccessible. Filling these gaps with human annotators is prohibitively expensive, error-prone, and time-consuming, leading model builders to increasingly consider synthetic data as a scalable alternative. However, existing synthetic data generation methods often rely on manual prompts, evolutionary algorithms, or extensive seed data from the target distribution — limiting their scalability, explainability, and control. In this paper, we introduce Simula: a novel reasoning-driven framework for data generation and evaluation. It employs a seedless, agentic approach to generate synthetic datasets at scale, allowing users to define desired dataset characteristics through an explainable and controllable process that enables fine-grained resource allocation. We show the efficacy of our approach on a variety of datasets, rigorously testing both intrinsic and downstream properties. Our work (1) offers guidelines for synthetic data mechanism design, (2) provides insights into generating and evaluating synthetic data at scale, and (3) unlocks new opportunities for developing and deploying AI in domains where data scarcity or privacy concerns are paramount.
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Sexual dimorphism in the complete connectome of the Drosophila male central nervous system
Stuart Berg
Isabella R Beckett
Marta Costa
Philipp Schlegel
Elizabeth C Marin
Aljoscha Nern
Stephan Preibisch
Wei Qiu
Shin-ya Takemura
Andrew Champion
Reed A. George
Gary Huang
William Katz
Christopher Ordish
Ken Hayworth
Eric Trautman
Vivek Jayaraman
Wyatt Korff
Geoffrey W Meissner
Sandro Romani
Jan Funke
Christopher Knecht
Stephan Saalfeld
Louis Scheffer
Scott Waddell
Gwyneth Card
Carlos Ribeiro
Michael B. Reiser
Harald Hess
Gerry Rubin
Gregory S.X.E. Jefferis
bioRxiv (2026)
Preview abstract
Sex differences in behaviour exist across all animals, typically under strong genetic regulation. In Drosophila, fruitless/doublesex transcription factors can identify dimorphic neurons but their organisation into functional circuits remains unclear.
We present the connectome of the entire Drosophila male central nervous system. This contains 166,691 neurons spanning the brain and nerve cord, fully proofread and annotated including fruitless/doublesex expression and 11,691 types. We provide the first comprehensive comparison between male and female brain connectomes to synaptic resolution, finding 7,205 isomorphic, 114 dimorphic, 262 male-specific and 69 female-specific types.
This resource enables analysis of full sensory-to-motor circuits underlying complex behaviours and the impact of dimorphic elements. Sex-specific/dimorphic neurons are concentrated in higher brain centres while the sensory and motor periphery are largely isomorphic. Within higher centres, male-specific connections are organised into hotspots defined by male-specific neurons or arbours. Numerous circuit switches reroute sensory information to form antagonistic circuits controlling opposing behaviours.
(Full author list included with the paper.)
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"It didn’t feel right but I needed a job so desperately": Understanding People's Emotions & Help Needs During Financial Scams
G. Jake Chanenson
Tara Matthews
Jessica McClearn
Sarah Meiklejohn
Mia Hassoun
2026
Preview abstract
Online financial scams represent a long-standing and serious threat for which people seek help. We present a study to understand people’s in situ motivations for engaging with scams and the help needs they express before, during, and after encountering a scam. We identify the main emotions scammers exploited (e.g., fear, hope) and characterize how they did so. We examine factors—such as financial insecurity and legal precarity—which elevate people’s risk of engaging with specific scams and experiencing harm. We indicate when people sought help and describe their help-seeking needs and emotions at different stages of the scam. We discuss how these needs could be met through the design of contextually-specific prevention, diagnostic, mitigation, and recovery interventions.
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