Publications
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
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1 - 15 of 11361 publications
Expert evaluation of LLM world models: A high-Tc superconductivity case study
Haoyu Guo
Maria Tikhanovskaya
Paul Raccuglia
Alexey Vlaskin
Chris Co
Scott Ellsworth
Matthew Abraham
Lizzie Dorfman
Peter Armitage
Chunhan Feng
Antoine Georges
Olivier Gingras
Dominik Kiese
Steve Kivelson
Vadim Oganesyan
Brad Ramshaw
Subir Sachdev
Senthil Todadri
John Tranquada
Eun-Ah Kim
Proceedings of the National Academy of Sciences (2026)
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Large Language Models (LLMs) show great promise as a powerful tool for scientific literature exploration. However, their effectiveness in providing scientifically accurate and comprehensive answers to complex questions within specialized domains remains an active area of research. This work evaluates the performance of six different LLM-based systems for answering scientific literature questions, including commercially available closed models and a custom retrieval-augmented generation (RAG) system capable of retrieving images alongside text. We conduct a rigorous expert evaluation of the systems in the domain of high-temperature cuprate superconductors, a research area that involves material science, experimental physics, computation, and theoretical physics. We use an expert-curated database of 1726 scientific papers and a set of 67 expert-formulated questions. The evaluation employs a multi-faceted rubric assessing balanced perspectives, factual comprehensiveness, succinctness, evidentiary support, and image relevance. Our results demonstrate that RAG-based systems, powered by curated data and multimodal retrieval, outperform existing closed models across key metrics, particularly in providing comprehensive and well-supported answers, and in retrieving relevant visual information. This study provides valuable insights into designing and evaluating specialized scientific literature understanding systems, particularly with expert involvement, while also highlighting the importance of rich, domain-specific data in such systems.
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While non-verbal behaviors and expressive movements are essential for natural human-robot interaction, existing methods often overlook a crucial element: the human’s internal cognitive state. Consequently, proactive multi-agent systems frequently interrupt humans at inopportune moments, leading to cognitive overload and decreased task performance. This paper introduces a framework for generating “cognitively aligned” multi-agent interactions, enhancing the ability of robotic systems to contextually defer communications during moments of high human mental workload. We present the design and implementation of a closed-loop architecture that explores the interplay between autonomous task execution and real-time neurophysiological focus. Utilizing a consumer-grade Brain-Computer Interface (BCI), our approach continuously monitors Electroencephalography (EEG) spectral band powers while a human performs a cognitive-load-inducing task. We propose a workload-driven pipeline where an HTTP-based signaling mechanism places a primary agent’s sensory inputs and audio outputs into a holding state upon detecting high cognitive load. This allows secondary agents to seamlessly process complex, delegated tasks in the background. Once the human’s cognitive state returns to a baseline, the primary agent releases the queued agent message. Our preliminary results demonstrate the feasibility of leveraging real-time signal processing, Large Language Models (LLMs), and physical robotic embodiments to create interrupt-aware, non-intrusive multi-agent systems.
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Optimizing large-language model (LLM) training and serving on large-sacle distributed systems with hundreds and thousands of accelerators is always a challenging task due to the fast evloving LLMs, strong domain expertise required, and various optimization goals from different worklaods. Existing methods rely on either handcrafted optimization performed by human experts, which is tedious and time-consuming or resource-intensive black-box searches, which lack the extensibility to keep pace with evolving models and hardware. To address this, we introduce PROMPTS, a novel multi-agent framework that complements traditional search methods with expert-informed reasoning. It automates the diagnosis of performance bottlenecks by synthesizing profiler data and leverages a knowledge base to propose optimized sharding configurations with detailed justifications.
Across eight real-world production workloads, PROMPTS demonstrated remarkable efficiency and accuracy, delivering performance improvements of up to 434%. These workloads spanned diverse model architectures, hardware platforms, computational scales, and various stages of the machine learning lifecycle (pre-training, serving, and post-training). In every case, the configuration adopted by human engineers was identified within the agent's top three proposals from a single invocation. Furthermore, the agent's top-ranked recommendation was the one ultimately adopted in 87.5% of cases, showcasing its ability to not only find optimized solutions, but also to correctly prioritize them. Our work establishes PROMPTS as a scalable, extensible, and explainable methodology for AI-assisted performance engineering in large-scale ML systems.
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Mid-air gestures in Extended Reality (XR) often lead to fatigue, discomfort and imprecision, limiting their suitability for extended use. Surface-based interactions offer a compelling alternative, providing improved accuracy, speed, and comfort. However, current egocentric vision-based methods struggle with reliable surface inputs due to challenges in hand tracking and surface-plane estimation from oblique and occluded viewing angles. To this extent, we introduce SurfaceXR, a novel sensor fusion approach that combines headset based hand tracking with micro-vibration data sampled from commodity smartwatch IMUs to enable precise and robust inputs on arbitrary surfaces. Our system is designed with flexibility in mind - it can function using only hand tracking, only IMU sensing, or optimally with both modalities combined. Our user study across 12 participants validates SurfaceXR's effectiveness in augmenting surface touch tracking and 8 class hand-surface gesture recognition, demonstrating significant improvements over single-modality approaches. Enabled by SurfaceXR, we demonstrate a series of interactive apps for both AR and VR, ranging from on-surface sketching, text entry and gesture based navigation.
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This disclosure describes systems and methods for a multi-agent framework that can automate and scale cognitive work. The framework can, for example, use a cognitive assembly line of specialized computational agents to perform tasks such as research and drafting. A beneficial component could be an adversarial review panel (ARP), which is a multi-agent review system where distinct agent personas critique a generated draft from varied perspectives. The structured feedback from the ARP can be used to automatically iterate on and refine the work product. This approach can improve the intellectual rigor of generated content and reduce the time required for production, which may allow human operators to focus on activities such as strategic oversight and final validation.
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AgentHands: Generating Interactive Hands Gestures for Spatially Grounded Agent Conversations in XR
Ziyi Liu
Proceedings of the 2026 CHI Conference on Human Factors in Computing Systems, ACM
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Communicating spatial tasks via text or speech creates ``a mental mapping gap'' that limits an agent’s expressiveness. Inspired by co-speech gestures in face-to-face conversation, we propose \textsc{AgentHands}, an LLM-powered XR system that equips agents with hands to render responses clearer and more engaging. Guided by a design taxonomy distilled from a formative study (N=10), we implement a novel pipeline to generate and render a hand agent that augments conversational responses with synchronized, space-aware, and interactive hand gestures: using a meta-instruction, \textsc{AgentHands} generates verbal responses embedded with \textit{GestureEvents} aligned to specific words; each event specifies gesture type and parameters. At runtime, a parser converts events into time-stamped poses and motions, driving an animation system that renders expressive hands synchronized with speech. In a within-subjects study (N=12), \textsc{AgentHands} increased engagement and made spatially grounded conversations easier to follow compared to a speech-only baseline.
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CoDaS: AI Co-Data-Scientist for Biomarker Discovery via Wearable Sensors
Juro Gottweis
CJ Park
Salman Rahman
Ahmed Metwally
Hong Yu
Ivor Rendulic
Yuzhe Yang
Petar Sirkovic
Daniel McDuff
Shwetak Patel
Nicolas Stroppa
Yubin Kim
Mark Malhotra
Orson Xu
Sam Schmidgall
Tim Althoff
Elahe Vedadi
Cynthia Breazeal
Hae Won Park
(2026)
Sexual dimorphism in the complete connectome of the Drosophila male central nervous system
Stuart Berg
Isabella R Beckett
Marta Costa
Philipp Schlegel
Elizabeth C Marin
Aljoscha Nern
Stephan Preibisch
Wei Qiu
Shin-ya Takemura
Andrew Champion
Reed A. George
Gary Huang
William Katz
Christopher Ordish
Ken Hayworth
Eric Trautman
Vivek Jayaraman
Wyatt Korff
Geoffrey W Meissner
Sandro Romani
Jan Funke
Christopher Knecht
Stephan Saalfeld
Louis Scheffer
Scott Waddell
Gwyneth Card
Carlos Ribeiro
Michael B. Reiser
Harald Hess
Gerry Rubin
Gregory S.X.E. Jefferis
bioRxiv (2026)
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Sex differences in behaviour exist across all animals, typically under strong genetic regulation. In Drosophila, fruitless/doublesex transcription factors can identify dimorphic neurons but their organisation into functional circuits remains unclear.
We present the connectome of the entire Drosophila male central nervous system. This contains 166,691 neurons spanning the brain and nerve cord, fully proofread and annotated including fruitless/doublesex expression and 11,691 types. We provide the first comprehensive comparison between male and female brain connectomes to synaptic resolution, finding 7,205 isomorphic, 114 dimorphic, 262 male-specific and 69 female-specific types.
This resource enables analysis of full sensory-to-motor circuits underlying complex behaviours and the impact of dimorphic elements. Sex-specific/dimorphic neurons are concentrated in higher brain centres while the sensory and motor periphery are largely isomorphic. Within higher centres, male-specific connections are organised into hotspots defined by male-specific neurons or arbours. Numerous circuit switches reroute sensory information to form antagonistic circuits controlling opposing behaviours.
(Full author list included with the paper.)
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Browser fingerprinting is the practice of tracking users across the Web by collecting attributes from their devices and combining them to create unique identifiers. This practice poses major privacy risks to users, and more than a decade of research has quantified fingerprinting risks due to various attributes, leading browser developers to implement many privacy-enhancing changes. Early work used Shannon entropy to quantify risks. However, Shannon entropy can grow with dataset size, limiting the ability to compare datasets and results. Researchers then introduced normalized entropy as a measure for comparing browser fingerprinting datasets of different sizes and numerous works followed using normalized entropy for this purpose.
We identify and address a resulting problem in the fingerprinting literature. We show normalized entropy is ill-suited to compare datasets of different sizes — it decreases as dataset size increases. We show this both analytically and empirically, leveraging a recently published dataset of browser attributes commonly used for fingerprinting.
Given the unmet need for a better fingerprinting risk measure, we define a minimal set of desired properties for such a measure: scale-invariance, monotonicity and estimability. We then propose to use Tsallis entropy as a more interpretable fingerprinting risk measure. We evaluate Shannon, normalized, and Tsallis entropy with respect to the properties, and prove that only Tsallis entropy satisfies all of them.
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VeriGuard: Enhancing LLM Agent Safety via Verified Code Generation
Dj Dvijotham
Mirko Montanari
ACL 2026
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Artificial intelligence is rapidly evolving, marked by the emergence of Large Language Model (LLM) agents – systems capable of complex reasoning, planning, and interaction with digital and physical environments. These agents, powered by advancements in LLMs, demonstrate remarkable capabilities across diverse domains, including finance, healthcare, web navigation, software development, and daily task assistance. Unlike traditional AI systems, LLM agents can perceive their surroundings, formulate multi-step plans, utilize external tools and APIs, access memory or knowledge bases, and execute actions to achieve specified goals. This ability to act upon the world, however, introduces significant safety and security challenges.
The safety paradigms developed for traditional LLMs, primarily focused on mitigating harmful textual outputs (e.g., toxicity, bias), are insufficient for safeguarding LLM agents. Agents interacting with dynamic environments and executing actions present a broader attack surface and new categories of risk. These include performing unsafe operations, violating privacy constraints through improper data handling or access control failures, deviating from user objectives (task misalignment), and susceptibility to novel manipulation techniques like indirect prompt injection and memory poisoning. Ensuring the trustworthy operation of these powerful agents is paramount, especially as they are integrated into high-stakes applications. To address this critical challenge, we introduce VeriGuard, a novel framework designed to enhance the safety and reliability of LLM agents by interactively verifying their policies and the actions. VeriGuard integrates a verification module that intercepts code-based actions proposed by the agent. In the first step, VeriGuard will generates and verifies the policies. The policies are rigorously checked against a set of predefined safety and security specifications Then each action will be verified to make sure it will align with the agent specification. This interactive verification loop ensures that the agent's behavior remains within safe operational bounds, effectively preventing the execution of harmful or unintended operations. By verifying each step, VeriGuard provides a robust safeguard, substantially improving the trustworthiness of LLM agents in complex, real-world environments.
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MoGen: Detailed Neuronal Morphology Generation via Point Cloud Flow Matching
Franz Rieger
International Conference on Learning Representations (ICLR) (2026)
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Biological neurons come in many shapes. High-fidelity generative modeling of their varied morphologies is challenging yet underexplored in neuroscience, and crucial for the subfield of connectomics. We introduce MoGen (Neuronal Morphology Generation), a flow matching model to generate high-resolution 3D point clouds of mouse cortex axon and dendrite fragments. This is enabled by an adaptation that injects local geometric context into a scalable latent transformer backbone, allowing for the generation of high-fidelity, realistic samples. To assess MoGen's generation quality, we propose a dedicated evaluation suite with interpretable geometric and topological features tailored to neuronal structures that we validate in a user study. MoGen's practical utility is showcased through controllable generation for visualization via smooth interpolation and a direct downstream application: we augment the training set of a shape plausibility classifier from a production connectomics neuron reconstruction pipeline with millions of generated samples, thereby improving classifier accuracy and reducing the number of remaining split and merge errors by 4.4%. We estimate this can reduce manual proofreading labor by over 157 person-years for reconstruction of a full mouse brain.
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Bridging the Dimensionality Gap: A Taxonomy and Survey of 2D Vision Model Adaptation for 3D Analysis
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The remarkable success of Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs) in 2D computer vision has catalyzed significant research into their adaptation for the complex domain of 3D analysis. However, a fundamental dichotomy exists between the regular, dense grid of 2D images and the irregular, sparse nature of 3D data formats such as point clouds and meshes. This paper provides a comprehensive survey and a novel intellectual framework for navigating this burgeoning field. Our core contribution is a new taxonomy that organizes adaptation strategies into three distinct families: (1) Data-centric methods, which project 3D data into 2D formats to leverage off-the-shelf 2D models; (2) Architecture-centric methods, which design intrinsic network modules to directly process 3D data; and (3) Hybrid methods, which synergistically combine pre-trained 2D features with 3D modeling processing pipelines to benefit from both rich visual priors and explicit geometric reasoning. Through this taxonomic lens, we conduct a systematic review and qualitative synthesis of the field. We illuminate the fundamental trade-offs between these families concerning computational complexity, reliance on large-scale pre-training, and the preservation of geometric inductive biases. Based on this analysis, we identify and discuss critical open challenges and chart promising future research directions, including the development of 3D foundation models, advancements in self-supervised learning for geometric data, and the deeper integration of multi-modal signals. This survey serves as an essential resource and roadmap for researchers seeking to understand and advance the state-of-the-art in 3D computer vision.
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An Empirical Study of Tablet Ergonomics: The Interplay of Temperature, Orientation, and Use Behaviors
Carmen Van Ommen
Mikki Phan
Arun Raghupathy
Daniel Huynh
Barbara Chaparro
Ergonomics in Design: The Quarterly of Human Factors Applications Journal (2026)
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To balance computational performance with thermal comfort, this study explores a consolidated hotspot architecture at the top center of a tablet. We tested hotspot (39°C, 43°C, 45°C, 47°C) and ambient temperatures (25°C, 35°C) with 60 participants, measuring perception, action likelihood, and expectation. The hotspot was observed away from high contact areas, with 43°C identified as the threshold for significant discomfort. Discomfort increased with portrait mode use and higher device and ambient temperatures, while active use duration influenced acceptability. The findings underscore the importance of thermal mapping and contextual sensing, with direct applications for software throttling thresholds of coated aluminum enclosures.
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Optical health sensing algorithms, such as SpO2, sleep monitoring, and metabolic health sensing, critically depend on the accurate measurement of optical emission from Light Emitting Diodes (LEDs) transmitted through user tissue and detected by a photodiode (PD). A significant challenge to the reliability of these measurements is the inherent degradation of LED optical emission intensity over time due to device aging. This degradation can confound the physiological changes being monitored. Our work quantifies the impact of LED aging on sensor signal integrity, specifically examining the Current Transfer Ratio (CTR), which is a key metric defining the ratio of received photocurrent to the LED drive current used for transmission in various health sensing algorithms. We investigate the degradation characteristics across LEDs of different wavelengths. Our findings indicate a relative CTR change due to degradation ranging from 1% to 8% within 100 hours of continuous operation which translates to approximately 3.5 to 7 years of device lifetime. Furthermore, we explore the non-linearity of this degradation and the observed initial ”overshoot” phenomenon in the CTR during aging. We discuss how understanding these dynamics could inform the development of robust specifications for different physiological sensing algorithms. Finally, we present several potential solutions to mitigate the effects of LED aging. During the product design phase, integrating a calibrating photodiode or compensating circuitry around the LED can help preemptively address degradation. In the application space, run-time calibration strategies employing two differently degraded optical paths offer a promising approach to maintain measurement accuracy.
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