Annalisa Pawlosky

Annalisa Pawlosky

Annalisa Pawlosky is the founder and principal investigator for the Google Accelerated Science biochemistry and molecular biology laboratory, a unique laboratory specifically designed for building custom assays that integrate with mathematical models, including machine learning, to accelerate new findings in the biological sciences. Annalisa conducted her postdoctoral work under Jan Liphardt and Michael Clarke as a Stanford Molecular Imaging Scholar postdoctoral fellow, and focused on discovering the mechanism behind the role of Usp16 in stem cell senescence. For this work, she built dimerization dependent protein sensors (ddFPs) between Usp16 and histone H2A for single molecule live cell imaging assays with TIRF. Annalisa received her PhD from MIT in the Harvard-MIT Division of Health Sciences and Technology program under the supervision of Alexander van Oudenaarden with her thesis titled Single molecule techniques to probe decision-making processes in developmental biology. She initiated mammalian work in the van Oudenaarden laboratory, and focused on studying patterning in mammalian organs during embryonic development. In particular, she studied and modeled Notch pathway regulated mechanisms behind cellular patterning for mammalian auditory outer hair cells with single molecule RNA FISH (smFISH).

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Authored Publications
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    ProtSeq: towards high-throughput, single-molecule protein sequencing via amino acid conversion into DNA barcodes
    Jessica Hong
    Michael Connor Gibbons
    Ali Bashir
    Diana Wu
    Shirley Shao
    Zachary Cutts
    Mariya Chavarha
    Ye Chen
    Lauren Schiff
    Mikelle Foster
    Victoria Church
    Llyke Ching
    Sara Ahadi
    Anna Hieu-Thao Le
    Alexander Tran
    Michelle Therese Dimon
    Phillip Jess
    iScience, 25 (2022), pp. 32
    Machine learning guided aptamer discovery
    Ali Bashir
    Geoff Davis
    Michelle Therese Dimon
    Qin Yang
    Scott Ferguson
    Zan Armstrong
    Nature Communications (2021)