Publications
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
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1 - 15 of 10257 publications
Triaging mammography with artificial intelligence: an implementation study
Sarah M. Friedewald
Sunny Jansen
Fereshteh Mahvar
Timo Kohlberger
David V. Schacht
Sonya Bhole
Dipti Gupta
Scott Mayer McKinney
Stacey Caron
David Melnick
Mozziyar Etemadi
Samantha Winter
Alejandra Maciel
Luca Speroni
Martha Sevenich
Arnav Agharwal
Rubin Zhang
Gavin Duggan
Shiro Kadowaki
Atilla Kiraly
Jie Yang
Basil Mustafa
Krish Eswaran
Shravya Shetty
Breast Cancer Research and Treatment (2025)
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Purpose
Many breast centers are unable to provide immediate results at the time of screening mammography which results in delayed patient care. Implementing artificial intelligence (AI) could identify patients who may have breast cancer and accelerate the time to diagnostic imaging and biopsy diagnosis.
Methods
In this prospective randomized, unblinded, controlled implementation study we enrolled 1000 screening participants between March 2021 and May 2022. The experimental group used an AI system to prioritize a subset of cases for same-visit radiologist evaluation, and same-visit diagnostic workup if necessary. The control group followed the standard of care. The primary operational endpoints were time to additional imaging (TA) and time to biopsy diagnosis (TB).
Results
The final cohort included 463 experimental and 392 control participants. The one-sided Mann-Whitney U test was employed for analysis of TA and TB. In the control group, the TA was 25.6 days [95% CI 22.0–29.9] and TB was 55.9 days [95% CI 45.5–69.6]. In comparison, the experimental group's mean TA was reduced by 25% (6.4 fewer days [one-sided 95% CI > 0.3], p<0.001) and mean TB was reduced by 30% (16.8 fewer days; 95% CI > 5.1], p=0.003). The time reduction was more pronounced for AI-prioritized participants in the experimental group. All participants eventually diagnosed with breast cancer were prioritized by the AI.
Conclusions
Implementing AI prioritization can accelerate care timelines for patients requiring additional workup, while maintaining the efficiency of delayed interpretation for most participants. Reducing diagnostic delays could contribute to improved patient adherence, decreased anxiety and addressing disparities in access to timely care.
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Society-Centric Product Innovation in the Era of Customer Obsession
International Journal of Science and Research Archive (IJSRA), Volume 14 - Issue 1 (2025)
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This article provides a comprehensive analysis of the evolving landscape of innovation in the technology sector, with a focus on the intersection of technological progress and social responsibility. The article explores key challenges facing the industry, including public trust erosion, digital privacy concerns, and the impact of automation on workforce dynamics. It investigates responsible innovation frameworks' emergence and implementation across various organizations, highlighting the transformation from traditional development approaches to more society-centric models. The article demonstrates how companies balance innovation speed with social responsibility, incorporate ethical considerations into their development processes, and address digital disparities across different demographics. By examining how companies balance the pace of innovation with ethical responsibilities, integrate social considerations into their processes, and address digital inequities across diverse demographics, the article underscores the transformative potential of these frameworks. Through insights into cross-functional teams, impact assessment tools, and stakeholder engagement strategies, it demonstrates how responsible innovation drives both sustainable business value and societal progress.
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There is a growing trend of legislation, regulation, and court rulings mandating the delisting of content from intermediary platforms. However, few, if any, studies have evaluated user reactions to edge cases involving the delisting of content of public interest. We administered a vignette-based online survey experiment to a representative sample of over 20,000 participants in five countries. We sought to understand user perceptions of delisting content from search engine results and the factors that influence them. While leaving information accessible in search engine results generally leads to warmer feelings towards those search engines, we find that contextual elements also impact this resulting warmth. In addition, we analyze respondents' knowledge and attitudes about the ``Right to be Forgotten'' (RTBF), perhaps the most well-known legislation on delisting. We find that respondents in countries with active RTBF legislation are more likely to support delisting, know more about RTBF, and support RTBF, and that RTBF knowledge/attitudes affects respondents' answers to our experiment. These results indicate a complex tension around delisting public-interest content from search engines' results. Experts sensitive to local context should perform reviews to ensure that delisting requests are handled in a way that meets users’ expectations.
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PreFix: Optimizing the Performance of Heap-Intensive Applications
Chaitanya Mamatha Ananda
Rajiv Gupta
Han Shen
CGO 2025: International Symposium on Code Generation and Optimization, Las Vegas, NV, USA (to appear)
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Analyses of heap-intensive applications show that a small fraction of heap objects account for the majority of heap accesses and data cache misses. Prior works like HDS and HALO have shown that allocating hot objects in separate memory regions can improve spatial locality leading to better application performance. However, these techniques are constrained in two primary ways, limiting their gains. First, these techniques have Imperfect Separation, polluting the hot memory region with several cold objects. Second, reordering of objects across allocations is not possible as the original object allocation order is preserved. This paper presents a novel technique that achieves near perfect separation of hot objects via a new context mechanism that efficiently identifies hot objects with high precision. This technique, named PreFix, is based upon Preallocating memory for a Fixed small number of hot objects. The program, guided by profiles, is instrumented to compute context information derived from
dynamic object identifiers, that precisely identifies hot object allocations that are then placed at predetermined locations in the preallocated memory. The preallocated memory region for hot objects provides the flexibility to reorder objects across allocations and allows colocation of objects that are part of a hot data stream (HDS), improving spatial locality. The runtime overhead of identifying hot objects is not significant as this optimization is only focused on a small number of static hot allocation sites and dynamic hot objects. While there is an increase in the program’s memory foot-print, it is manageable and can be controlled by limiting the size of the preallocated memory. In addition, PreFix incorporates an object recycling optimization that reuses the same preallocated space to store different objects whose lifetimes are not expected to overlap. Our experiments with 13 heap-intensive applications yields reductions in execution times ranging from 2.77% to 74%. On average PreFix reduces execution time by 21.7% compared to 7.3% by HDS and 14% by HALO. This is due to PreFix’s precision in hot object identification, hot object colocation, and low runtime overhead.
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The problem of contract design addresses the challenge of moral hazard in principle-agent setups. The agent exerts costly efforts that produce a random outcome with an associated reward for the principal. Moral hazard refers to the tension that the principal cannot observe the agent’s effort level hence needs to incentivize the agent only through rewarding the realized effort outcome, i.e., the contract. Bayesian contract design studies the principal’s design problem of an optimal contract when facing an unknown agent characterized by a private Bayesian type. In its most general form, the agent’s type is inherently “multi-parameter” and can arbitrarily affect both the agent’s productivity and effort costs. In contrast, a natural single-parameter setting of much recent interest simplifies the agent’s type to a single value that describes the agent’s cost per unit of effort, whereas agents’ efforts are assumed to be equally
productive.
The main result of this paper is an almost approximation-preserving polynomial-time reduction from the most general multi-parameter Bayesian contract design (BCD) to single-parameter BCD. That is, for any multi-parameter BCD instance I^M, we construct a single-parameter instance I^S such that any β-approximate contract (resp. menu of contracts) of I^S can in turn be converted to a (β − ϵ)-approximate contract (resp. menu of contracts) of I^M. The reduction is in time polynomial in the input size and log(1/ϵ); moreover, when β = 1 (i.e., the given single-parameter solution is exactly optimal), the dependence on 1/ϵ can be removed, leading to a polynomial-time exact reduction. This efficient reduction is somewhat surprising because in the closely related problem of Bayesian mechanism design, a polynomial-time reduction from multi-parameter to single-parameter setting is believed to not exist. Our result demonstrates the intrinsic difficulty of addressing moral hazard in Bayesian contract design, regardless of being single-parameter or multi-parameter.
As byproducts, our reduction answers two open questions in recent literature of algorithmic contract design: (a) it implies that optimal contract design in single-parameter BCD is not in APX unless P=NP even when the agent’s type distribution is regular, answering the open question of [3] in the negative; (b) it implies that the principal’s (order-wise) tight utility gap between using a menu of contracts and a single contract is Θ(n) where n is the number of actions, answering the major open question of [27] for the single-parameter case.
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Scaling Laws for Downstream Task Performance in Machine Translation
Natalia Ponomareva
Hussein Hazimeh
Sanmi Koyejo
International Conference on Learning Representations (ICLR) (2025) (to appear)
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Scaling laws provide important insights that can guide the design of large language models (LLMs). Existing work has primarily focused on studying scaling laws for pretraining (upstream) loss. However, in transfer learning settings, in which LLMs are pretrained on an unsupervised dataset and then finetuned on a downstream task, we often also care about the downstream performance. In this work, we study the scaling behavior in a transfer learning setting, where LLMs are finetuned for machine translation tasks. Specifically, we investigate how the choice of the \emph{pretraining} data and its size affect downstream performance (translation quality) as judged by: downstream cross-entropy and translation quality metrics such as BLEU and COMET scores. Our experiments indicate that the size of the finetuning dataset and the distribution alignment between the pretraining and downstream data significantly influence the scaling behavior. With sufficient alignment, both downstream cross-entropy and translation quality scores improve monotonically with more pretraining data. In such cases, we show that it is possible to predict the downstream translation quality metrics with good accuracy using a log-law. However, there are cases where moderate misalignment causes the downstream translation scores to fluctuate or get worse with more pretraining, whereas downstream cross-entropy monotonically improves. By analyzing these, we provide new practical insights for choosing appropriate pretraining data.
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A Strategic Framework for AI Product Development and Evaluation in Enterprise Software
International Journal of Computer Engineering and Technology (IJCET), Volume 16, Issue 1 (2025)
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This article presents a comprehensive framework for developing and evaluating AI products in enterprise software systems, addressing the critical challenges organizations face during AI transformation initiatives. The article introduces a structured approach to decision-making for AI integration, encompassing ROI evaluation, user value assessment, and business impact analysis. It establishes distinct methodologies for both assistive and autonomous AI systems, providing detailed metrics for measuring success and performance across different implementation scenarios. Across various industries, the framework has shown potential in reducing implementation time, increasing user adoption rates, and enhancing overall project success rates, highlighting its practical applicability. The article methodology combines theoretical analysis with practical case studies, resulting in a flexible yet robust framework that can adapt to various organizational contexts. The framework's primary contribution lies in its practical approach to bridging the gap between theoretical AI capabilities and real-world implementation challenges, offering product leaders a systematic methodology for AI product development and evaluation. By addressing both current implementation challenges and future scalability requirements, this framework provides organizations with a foundational tool for navigating their AI transformation journey while maintaining a focus on measurable business outcomes and user value creation.
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Databases in the Era of Memory-Centric Computing
Anastasia Ailamaki
Lawrence Benson
Helena Caminal
Jana Gičeva
Eric Seldar
Lisa Wu Wills
2025
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The increasing disparity between processor core counts and memory bandwidth, coupled with the rising cost and underutilization of memory, introduces a performance and cost Memory Wall and presents a significant challenge to the scalability of database systems. We argue that current processor-centric designs are unsustainable, and we advocate for a shift towards memory-centric computing, where disaggregated memory pools enable cost-effective scaling and robust performance. Database systems are uniquely positioned to leverage memory-centric systems because of their intrinsic data-centric nature. We demonstrate how memory-centric database operations can be realized with current hardware, paving the way for more efficient and scalable data management in the cloud.
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Context is Key for Agent Security
Lillian Tsai
Eugene Bagdasaryan
arXiv (2025)
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Judging the safety of an action, whether taken by a human or a system, must take into account the context in which the action takes place. For example, deleting an email from a user's mailbox may or may not be appropriate depending on the email's content, the user's goals, or even available space. Systems today that make these judgements---providing security against harmful or inappropriate actions---rely on manually-crafted policies or user confirmation for each relevant context. With the upcoming deployment of systems like generalist agents, we argue that we must rethink security designs to adapt to the scale of contexts and capabilities of these systems. As a first step, this paper explores contextual security in the domain of agents and proposes contextual security for agents (Conseca), a framework to generate just-in-time, contextual, and human-verifiable security policies.
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Beyond Touchscreens: Designing for Co-Occurring Accessibility Needs
Melissa Barnhart Wantland
Mai Kobori
Universal Access in Human-Computer Interaction, Springer-Verlag (2025) (to appear)
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Today’s smartphone interactions are typically designed with one primary preset, accompanied by customization settings that can be manually adjusted. To promote the creation of contextually aware experiences, researchers have highlighted the factors that influence mobile device usage in the ability-based design framework. This paper expands upon existing frameworks and contributes to an empirical understanding of smartphone accessibility. Through a 10-day longitudinal diary study and video interview with 24 individuals who do and do not identify as having a disability, the research also illustrates the reactions of reattempt, adaptation, and avoidance, which were used in response to a lack of smartphone accessibility. Despite experiencing scenarios where accessibility settings could be leveraged, 20 out of 24 participants did not use accessibility settings on their smartphone. A total of 12 out of 24 participants tried accessibility settings on their smartphones, however identifying accessibility was not for them. This work highlights the need to shift current design practices to better serve the accessibility community.
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Augmenting LLMs with context leads to improved performance across many applications. Despite much research on Retrieval Augmented Generation (RAG) systems, an open question is whether errors arise because LLMs fail to utilize the context from retrieval or the context itself is insufficient to answer the query. To shed light on this, we develop a new notion of sufficient context, along with a way to classify instances that have enough information to answer the query. We then use sufficient context to analyze several models and datasets. By stratifying errors based on context sufficiency, we find that proprietary LLMs (Gemini, GPT, Claude) excel at answering queries when the context is sufficient, but often output incorrect answers instead of abstaining when the context is not. On the other hand, open-source LLMs (Llama, Mistral, Gemma) hallucinate or abstain often, even with sufficient context. We further categorize cases when the context is useful, and improves accuracy, even though it does not fully answer the query and the model errs without the context. Building on our findings, we explore ways to reduce hallucinations in RAG systems, including a new selective generation method that leverages sufficient context information for guided abstention. Our method improves the fraction of correct answers among times where the model responds by 2--10% for Gemini, GPT, and Gemma.
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Linear Elastic Caching via Ski Rental
Todd Lipcon
The biennial Conference on Innovative Data Systems Research (2025)
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In this work we study the Linear Elastic Caching problem, where the goal is to minimize the total cost of a cache inclusive of not just its misses, but also its memory footprint integrated over time. We demonstrate a theoretical connection to the classic ski rental problem and propose a practical algorithm that combines online caching algorithms with ski rental policies. We also introduce a lightweight machine learning-based algorithm for ski rental that is optimized for production workloads and is easy to integrate within existing database systems. Evaluations on both production workloads in Google Spanner and publicly available traces show that the proposed elastic caching approach can significantly reduce the total cache cost compared to traditional fixed-size cache policies.
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Gemini & Physical World: Large Language Models Can Estimate the Intensity of Earthquake Shaking from Multi-Modal Social Media Posts
Marc Stogaitis
Tajinder Gadh
Richard Allen
Alexei Barski
Robert Bosch
Patrick Robertson
Youngmin Cho
Nivetha Thiruverahan
Aman Raj
Geophysical Journal International (2025), ggae436
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This paper presents a novel approach for estimating the ground shaking intensity using real-time social media data and CCTV footage. Employing the Gemini 1.5 Pro’s (Reid et al. 2024) model, a multi-modal language model, we demonstrate the ability to extract relevant information from unstructured data utilizing generative AI and natural language processing. The model’s output, in the form of Modified Mercalli Intensity (MMI) values, align well with independent observational data. Furthermore, our results suggest that beyond its advanced visual and auditory understanding abilities, Gemini appears to utilize additional sources of knowledge, including a simplified understanding of the general relationship between earthquake magnitude, distance, and MMI intensity, which it presumably acquired during its training, in its reasoning and decision-making processes. These findings raise intriguing questions about the extent of Gemini's general understanding of the physical world and its phenomena. Gemini’s ability to generate results consistent with established scientific knowledge highlights the potential of LLMs like Gemini in augmenting our understanding of complex physical phenomena such as earthquakes. More specifically, the results of this study highlight the potential of LLMs like Gemini to revolutionize citizen seismology by enabling rapid, effective, and flexible analysis of crowdsourced data from eyewitness accounts for assessing earthquake impact and providing crisis situational awareness. This approach holds a great promise for improving early warning systems, disaster response, and overall resilience in earthquake-prone regions. This study provides a significant step toward harnessing the power of social media and AI for earthquake disaster mitigation.
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We consider the problem of auto-bidding in online advertising from the perspective of a single advertiser. The goal of the advertiser is to maximize their value under the Return-on-Spend (RoS) constraint, with performance measured in terms of \emph{regret} against the optimal offline solution that knows all queries a priori. Importantly, the value of the item is \textit{unknown} to the bidder ahead of time. The goal of the bidder is to quickly identify the optimal bid, while simultaneously satisfying budget and RoS constraints. Using a simple UCB-style algorithm, we provide the first result which achieves optimal regret and constraint violation for this problem.
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InstructPipe: Building Visual Programming Pipelines in Visual Blocks with Human Instructions Using LLMs
Zhongyi Zhou
Jing Jin
Xiuxiu Yuan
Jun Jiang
Jingtao Zhou
Yiyi Huang
Kristen Wright
Jason Mayes
Mark Sherwood
Alex Olwal
Ram Iyengar
Na Li
Proceedings of the 2025 CHI Conference on Human Factors in Computing Systems (CHI), ACM, pp. 23
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Visual programming provides beginner-level programmers with a coding-free experience to build their customized pipelines. Existing systems require users to build a pipeline entirely from scratch, implying that novice users need to set up and link appropriate nodes all by themselves, starting from a blank workspace. We present InstructPipe, an AI assistant that enables users to start prototyping machine learning (ML) pipelines with text instructions. We designed two LLM modules and a code interpreter to execute our solution. LLM modules generate pseudocode of a target pipeline, and the interpreter renders a pipeline in the node-graph editor for further human-AI collaboration. Technical evaluations reveal that InstructPipe reduces user interactions by 81.1% compared to traditional methods. Our user study (N=16) showed that InstructPipe empowers novice users to streamline their workflow in creating desired ML pipelines, reduce their learning curve, and spark innovative ideas with open-ended commands.
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