Publications
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
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1 - 15 of 11342 publications
An AI system to help scientists write expert-level empirical software
Eser Aygün
Anastasiya Belyaeva
Gheorghe Comanici
Hao Cui
Renee Johnston
Zahra Shamsi
David Smalling
James Thompson
Sarah Martinson
Lai Wei
Yuchen Zhou
Qian-Ze Zhu
Matthew Abraham
Erica Brand
Anna Bulanova
Jeffrey Cardille
Chris Co
Scott Ellsworth
Grace Joseph
Malcolm Kane
Ryan Krueger
Johan Kartiwa
Jackson Cui
Paul Raccuglia
Julie Wang
Kat Chou
James Manyika
Lizzie Dorfman
Shibl Mourad
Nature (2026)
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The cycle of scientific discovery is frequently bottlenecked by the slow, manual creation of software to support computational experiments. To address this, we present Empirical Research Assistance (ERA), an AI system that creates expert-level scientific software whose goal is to maximize a quality metric. The system uses a Large Language Model (LLM) and Tree Search (TS) to systematically improve the quality metric and intelligently navigate the large space of possible solutions. ERA achieves expert-level results when it explores and integrates complex research ideas from external sources. The effectiveness of tree search is demonstrated across a diverse range of tasks. In bioinformatics, ERA discovered 40 novel methods for single-cell data analysis that outperformed the top human-developed methods on a public leaderboard. In epidemiology, ERA generated 14 models that outperformed the CDC ensemble and all other individual models for forecasting COVID-19 hospitalizations. ERA also produced expert-level software for geospatial analysis, neural activity prediction in zebrafish, and numerical solution of integrals, and a novel rule-based construction for time series forecasting. By devising and implementing novel solutions to diverse tasks, ERA represents a significant step towards accelerating scientific progress.
Keywords: Tree Search, Generative AI, Scorable Scientific Tasks, Empirical Software
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While non-verbal behaviors and expressive movements are essential for natural human-robot interaction, existing methods often overlook a crucial element: the human’s internal cognitive state. Consequently, proactive multi-agent systems frequently interrupt humans at inopportune moments, leading to cognitive overload and decreased task performance. This paper introduces a framework for generating “cognitively aligned” multi-agent interactions, enhancing the ability of robotic systems to contextually defer communications during moments of high human mental workload. We present the design and implementation of a closed-loop architecture that explores the interplay between autonomous task execution and real-time neurophysiological focus. Utilizing a consumer-grade Brain-Computer Interface (BCI), our approach continuously monitors Electroencephalography (EEG) spectral band powers while a human performs a cognitive-load-inducing task. We propose a workload-driven pipeline where an HTTP-based signaling mechanism places a primary agent’s sensory inputs and audio outputs into a holding state upon detecting high cognitive load. This allows secondary agents to seamlessly process complex, delegated tasks in the background. Once the human’s cognitive state returns to a baseline, the primary agent releases the queued agent message. Our preliminary results demonstrate the feasibility of leveraging real-time signal processing, Large Language Models (LLMs), and physical robotic embodiments to create interrupt-aware, non-intrusive multi-agent systems.
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**Agentic Engineering** is the rigorous discipline of treating Large Language Models as semi-autonomous systems that execute complex, multi-step workflows (trajectories) based on verifiable specifications, rather than using them as simple autocomplete engines.
Here is a brief summary of its core principles:
* **Main Goals:** It aims to maximize the agent's autonomous run-time, multiply a single engineer's impact by running parallel tasks, and offload tedious boilerplate coding.
* **The "Harness":** A raw model is virtually useless without heavy investment in a harness—comprising tools, system prompts, and strict guardrails—to reliably guide the model and enforce coding policies.
* **Loss of Micro-Control:** Engineers must surrender idiosyncratic stylistic preferences; if the agent's code passes automated linters and tests, it is accepted.
* **Meta-Debugging:** When failures occur, engineers no longer fix code syntax. Instead, they debug the workflow itself—adjusting the agent's tools, search queries, or prompt constraints to ensure repeatable success.
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Audio Description ( AD) provides essential access to visual media for blind and low vision ( BLV) audiences. Yet current AD production tools remain largely inaccessible to BLV video creators, who possess valuable expertise but face barriers due to visually- driven interfaces. We present ADCanvas, a multimodal authoring system that supports non- visual control
over audio description ( AD) creation. ADCanvas combines conversational interaction with keyboard- based playback control and a plain- text, screen reader–
accessible editor to support end- to- end AD authoring and visual question answering ( VQA). Combining screen- reader- friendly controls with a multimodal
LLM agent, ADCanvas supports live VQA, script generation, and AD modification. Through a user study with 12 BLV video creators, we find that users adopt
the conversational agent as an informational aide and drafting assistant, while maintaining agency through verification and editing. For example, participants
saw themselves as curators who received information from the model and filtered it down for their audience. Our findings offer design implications for
accessible media tools, including precise editing controls, accessibility support for creative ideation, and configurable rules for human- AI collaboration.
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Rank aggregation is a task of combining the rankings of items from multiple users into a single ranking that best represents the users' rankings. Alabi et al. (AAAI'22) presents differentially-private (DP) polynomial-time approximation schemes (PTASes) and 5-approximation algorithms with certain additive errors for the Kemeny rank aggregation problem in both central and local models. In this paper, we present improved DP PTASes with smaller additive error in the central model. Furthermore, we are first to study the footrule rank aggregation problem under DP. We give a near-optimal algorithm for this problem; as a corollary, this leads to 2-approximation algorithms with the same additive error as the 5-approximation algorithms of Alabi et al. for the Kemeny rank aggregation problem in both central and local models.
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Identifying Hearing Difficulty Moments in Conversational Audio
Jack Collins
Adrian Buzea
Chris Collier
Alejandro Ballesta Rosen
Julian Maclaren
Kelly Miles
Simon Carlile
Trends in Hearing (2026)
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Individuals regularly experience Hearing Difficulty Moments in everyday conversation. Identifying Hearing Difficulty Moments has particular significance in the field of hearing assistive technology where timely interventions are key for real-time hearing assistance. In this article, we propose and compare machine learning solutions for the temporal detection of segments containing Hearing Difficulty Moments in conversational audio. We show that audio language models, through their multimodal reasoning capabilities, can achieve state-of-the-art results for this task, significantly outperforming a simple automatic speech recognition (ASR) hotword heuristic and a more conventional fine-tuning approach with Wav2Vec, an audio-only input architecture that is state-of-the-art for ASR.
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Deep-learning methods have boosted the analytical power of Raman spectroscopy, yet they still require large, task-specific, labeled datasets and often fail to transfer across application domains. The study explores pre-trained encoders as a solution. Pre-trained encoders have significantly impacted Natural Language Processing and Computer Vision with their ability to learn transferable representations that can be applied to a variety of datasets, significantly reducing the amount of time and data required to create capable models. The following work puts forward a new approach that applies these benefits to Raman Spectroscopy. The proposed approach, RSPTE (Raman Spectroscopy Pre-Trained Encoder), is designed to learn generalizable spectral representations without labels. RSPTE employs a novel domain adaptation strategy using unsupervised Barlow Twins decorrelation objectives to learn fundamental spectral patterns from multi-domain Raman Spectroscopy datasets containing samples from medicine, biology, and mineralogy. Transferability is demonstrated through evaluation on several models created by fine-tuning RSPTE for different application domains: Medicine (detection of Melanoma and COVID), Biology (Pathogen Identification), and Agriculture. As an example, using only 20% of the dataset, models trained with RSPTE achieve accuracies ranging 50%–86% (depending on the dataset used) while without RSPTE the range is 9%–57%. Using the full dataset, accuracies with RSPTE range 81%–97%, and without pretraining 51%–97%. Current methods and state-of-the-art models in Raman Spectroscopy are compared to RSPTE for context, and RSPTE exhibits competitive results, especially with less data as well. These results provide evidence that the proposed RSPTE model can effectively learn and transfer generalizable spectral features across different domains, achieving accurate results with less data in less time (both data collection time and training time).
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This writeup defines the Hydration Proxy Pattern, a framework for building stateful conversational data systems over stateless LLM APIs. It describes a platform-agnostic approach to decoupling persistence from the AI provider through secure server-side intermediation and hybrid storage tiers. The abstract provides a blueprint for managing the "Persistence Gap" in enterprise AI integrations, detailing high-level strategies for session history management, streaming, and multi-stage semantic grounding without disclosing specific internal implementation details.
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Large language models (LLMs) are trained on web-scale corpora that exhibit steep power-law distributions, in which the distribution of knowledge is highly long-tailed, with most appearing infrequently. While scaling has improved average-case performance, persistent failures on low-frequency, domain-specific, cultural, and temporal knowledge remain poorly characterized. This paper develops a structured taxonomy and analysis of long-tail knowledge in large language models, synthesizing prior work across technical and sociotechnical perspectives.
We organize the literature along four complementary axes: how long-tail knowledge is defined, the mechanisms by which it is lost or distorted during training and inference, the technical interventions proposed to mitigate these failures, and the implications of these failures for fairness, accountability, transparency, and user trust. We further examine how existing evaluation practices obscure tail behavior and complicate accountability for rare but consequential failures. The paper concludes by identifying open challenges related to privacy, sustainability, and governance that constrain long-tail knowledge representation. Taken together, this paper provides a unifying conceptual framework for understanding how long-tail knowledge is defined, lost, evaluated, and manifested in deployed language model systems.
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An experimental evaluation of an AI-powered interactive learning platform
Nicole Miller
Yael Haramaty
Lidan Hackmon
Lior Belinsky
Abraham Oritz Tapia
Lucy Tootill
Scott Siebert
Frontiers in Artificial Intelligence (2026) (to appear)
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Generative AI, which is capable of transforming static content into dynamic learning experiences, holds the potential to revolutionize student engagement in educational contexts. However, questions still remain around whether or not these tools are effective at facilitating student learning. In this research, we test the effectiveness of an AI-powered platform incorporating multiple representations and assessment through Learn Your Way, an experimental research platform that transforms textbook chapters into dynamic visual and audio representations. Through a between-subjects, mixed methods experiment with 60 US-based students, we demonstrate that students who used Learn Your Way had a more positive learning experience and had better learning outcomes compared to students learning the same content through a digital textbook. These findings indicate that AI-driven tools, capable of providing choice among interactive representations of content, constitute an effective and promising method for enhancing student learning.
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System for a Secure, Outcome-Based Synthetic Labor Market Using Trusted Execution Environments
Patent (2026)
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Some artificial intelligence provisioning models that function as tools for human users or rely on labor arbitrage can present challenges for organizations, such as managing personnel rather than task outcomes and introducing data security risks. An architecture is described for an outcome-based synthetic labor market in which autonomous computational agents can be compensated based on verified task completion. The framework can leverage trusted execution environments to create secure hardware enclaves for processing sensitive data, which can render the data cryptographically inaccessible to a host system or agent provider. This approach can facilitate a secure, transactional market for autonomous professional execution, which may enable a shift from managing labor resources to procuring verified outcomes from a pool of specialized agents.
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Digital Shadow AI Risk Theoretical Framework (DART): A Framework for Managing Data Disclosure and Privacy Risks of AI tools at Work
Master's Thesis (2026)
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The accelerated integration of generative AI technologies and agentic AI tools, particularly those like ChatGPT, into workplace settings has introduced complex challenges concerning data governance, regulatory compliance, and organizational privacy (GDPR 2016; CCPA/CPRA). This study introduces the Digital Shadow AI Risk Theoretical Framework (DART)—a novel theoretical framework designed to systematically identify, classify, and address the latent risks arising from the widespread, and often unregulated, use of AI systems in professional environments (NIST, 2023; OECD AI Policy Observatory, 2023). DART introduces six original, interrelated constructs developed in this study: Unintentional Disclosure Risk, Trust-Dependence Paradox, Data Sovereignty Conflict, Knowledge Dilution Phenomenon, Ethical Black Box Problem, and Organizational Feedback Loops. Each construct reflects a unique dimension of risk that emerges as organizations increasingly rely on AI-driven tools for knowledge work and decision-making.
The framework is empirically tested through a mixed-methods research design involving hypothesis testing and statistical analysis of behavioral data gathered from cross-sectional surveys of industry professionals. Two cross-industry surveys (Survey-1: 416 responses, 374 analyzed; Survey-2: 203 responses, 179 analyzed) and CB-SEM tests supported seven of eight hypotheses; H4 (sovereignty) was not significant; H7 (knowledge dilution) was confirmed in replication. The findings highlight critical gaps in employee training, policy awareness, and risk mitigation strategies—underscoring the urgent need for updated governance frameworks, comprehensive AI-use policies, and targeted educational interventions. This paper contributes to emerging scholarship by offering a robust model for understanding and mitigating digital risks in AI-enabled workplaces, providing practical implications for compliance officers, risk managers, and organizational leaders aiming to harness the benefits of generative AI responsibly and securely. The novelty of DART lies in its explicit theorization of workplace-level behavioral risks—especially Shadow AI, which unlike Shadow IT externalizes organizational knowledge into adaptive systems—thereby offering a unified framework that bridges fragmented literatures and grounds them in empirical evidence.
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GUIDE: A Benchmark for User Context Understanding and Assistance in GUI Workflow Videos
Saelyne Yang
Jaesang Yu
Yi-Hao Peng
Kevin Qinghong Lin
Jae Won Cho
Juho Kim
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) (2026)
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Graphical User Interface (GUI) agents have the potential to assist users in interacting with complex software. While prior research has primarily focused on automating user actions through clicks and keystrokes, this paradigm overlooks human intention, where users value the ability to explore, iterate, and refine their ideas while maintaining agency.To move beyond automation and toward collaboration, GUI agents must understand what users are doing and why. We introduce GUIDE (GUI Understanding, Intent, and Help Decision Evaluation), a benchmark that evaluates AI models on their ability to perceive user behavior, infer intent, and provide assistance in open-ended GUI tasks. GUIDE consists of 67.5 hours of screen recordings from 120 novice user demonstrations with think-aloud narrations that surface user intent, across 10 complex software (e.g., PowerPoint, Photoshop). GUIDE defines three tasks—(i) Behavior State Detection, (ii) Intent Prediction, and (iii) Help Prediction that test a model’s ability to recognize behavior state, reason about goals, and decide when and how to help. Evaluations across eight state-of-the-art multimodal models reveal that all models struggled with the tasks, achieving only 44.6% and 55.0% accuracy on behavior state and help prediction. However, providing user context such as behavioral state and intent significantly improved the performance, raising help prediction by up to 50.2%. These results highlight the critical role of structured user understanding in effective assistance.Our benchmark provides a path toward GUI agents that go beyond automation to become truly user-aware collaborators.
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Efficient, Property-Aligned Fan-Out Retrieval via RL-Compiled Diffusion
Patrick Jiang
Judith Li
Moonkyung Ryu
Lily Hu
Kun Su
Liam Hebert
Hao Peng
Jiawei Han
Dima Kuzmin
Efficient, Property-Aligned Fan-Out Retrieval via RL-Compiled Diffusion, Seoul, South Korea (2026)
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Many modern retrieval problems are set-valued: given a broad intent, the system must return a collection of results that optimizes higher-order properties (e.g., diversity, coverage, complementarity, coherence) while staying grounded to a fixed database. These objectives are inherently non-decomposable, creating a training bottleneck because property-aligned (query, content) supervision is scarce. Reinforcement learning (RL) can optimize set-level objectives via interaction, but deploying an RL-tuned LLM for fan-out retrieval is expensive at query time. Diffusion-based generative retrieval enables efficient single-pass fan-out in embedding space, but requires objective-aligned training targets. We propose R4T (Retrieve-for-Train), which uses RL once as an objective transducer: (i) train a fan-out LLM with composite set-level rewards, (ii) synthesize objective-consistent training pairs, and (iii) train a lightweight diffusion retriever to model the conditional distribution of set-valued outputs. Across Polyvore and a large-scale music playlist dataset, R4T improves retrieval quality over strong baselines while reducing query-time fan-out latency by an order of magnitude.
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We introduce AASE (Activation-based AI Safety Enforcement), a framework for post-perception safety monitoring in large language models. Unlike pre-perception approaches that analyze input or output text, AASE monitors the model's internal activation patterns—what the model "understands" rather than what text it processes or generates—enabling detection of safety-relevant states before harmful outputs are produced. The framework comprises three techniques: Activation Fingerprinting (AF) for harmful content detection, Agent Action Gating (AAG) for prompt injection defense, and Activation Policy Compliance (APC) for enterprise policy enforcement. We introduce paired contrastive training to isolate safety-relevant signals from confounding factors such as topic and style, addressing signal entanglement in polysemantic activations. Validation across 7 models from 3 architecture families shows strong class separation: Gemma-2-9B achieves AUC 1.00 with 7.2σ separation across all probes; AAG achieves AUC ≥0.88 across all models on the InjecAgent benchmark; APC achieves 0.97-1.00 AUC across three enterprise policies. Model size correlates with probe quality—Gemma-2-9B (7.2σ separation) outperforms Gemma-2-2B (4.3σ). All techniques survive INT4 quantization with minimal separation degradation. AASE is 9× faster than Llama Guard 3 (33ms vs 306ms) with higher TPR (88% vs 50%) at a tunable threshold that trades FPR for detection sensitivity, adding only 0.002ms probe overhead to existing inference.
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