Publications
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
Our teams aspire to make discoveries that impact everyone, and core to our approach is sharing our research and tools to fuel progress in the field.
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1 - 15 of 10129 publications
Towards Generalist Biomedical AI
Danny Driess
Andrew Carroll
Chuck Lau
Ryutaro Tanno
Ira Ktena
Anil Palepu
Basil Mustafa
Aakanksha Chowdhery
Simon Kornblith
Philip Mansfield
Sushant Prakash
Renee Wong
Sunny Virmani
Sara Mahdavi
Bradley Green
Ewa Dominowska
Joelle Barral
Karan Singhal
Pete Florence
NEJM AI (2024)
Preview abstract
BACKGROUND: Medicine is inherently multimodal, requiring the simultaneous interpretation and integration of insights between many data modalities spanning text, imaging, genomics, and more. Generalist biomedical artificial intelligence systems that flexibly encode, integrate, and interpret these data might better enable impactful applications ranging from scientific discovery to care delivery.
METHODS: To catalyze development of these models, we curated MultiMedBench, a new multimodal biomedical benchmark. MultiMedBench encompasses 14 diverse tasks, such as medical question answering, mammography and dermatology image interpretation, radiology report generation and summarization, and genomic variant calling. We then introduced Med-PaLM Multimodal (Med-PaLM M), our proof of concept for a generalist biomedical AI system that flexibly encodes and interprets biomedical data including clinical language, imaging, and genomics with the same set of model weights. To further probe the capabilities and limitations of Med-PaLM M, we conducted a radiologist evaluation of model-generated (and human) chest x-ray reports.
RESULTS: We observed encouraging performance across model scales. Med-PaLM M reached performance competitive with or exceeding the state of the art on all MultiMedBench tasks, often surpassing specialist models by a wide margin. In a side-by-side ranking on 246 retrospective chest x-rays, clinicians expressed a pairwise preference for Med-PaLM Multimodal reports over those produced by radiologists in up to 40.50% of cases, suggesting potential clinical utility.
CONCLUSIONS: Although considerable work is needed to validate these models in real-world cases and understand if cross-modality generalization is possible, our results represent a milestone toward the development of generalist biomedical artificial intelligence systems.
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SAC125 - SSAC Report on Registrar Nameserver Management
Gautam Akiwate
Tim April
kc claffy
Internet Corporation for Assigned Names and Numbers (ICANN), ICANN Security and Stability Advisory Committee (SSAC) Reports and Advisories (2024), pp. 56
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During domain registration, a minimum of two nameservers are typically required, and this
remains a requirement for any future updates to the domain. Often, domains are delegated to
nameservers that are subordinate to some other domains, creating inter-domain dependencies.
This network of dependencies creates a scenario where the functionality of a domain depends
on the operational status of another domain. This setup lacks contractual or procedural
safeguards against disruption or misuse, especially when the nameserver parent domain expires.
Most registries forbid deleting an expired domain if other domains depend on it for name
resolution. These constraints aim to prevent disruptions in DNS resolution for the dependent
domains. However, this also means that the expired domain remains in a liminal state, neither
fully operational nor completely removed. When registrars cannot delete expired domains with
dependents, they are forced to bear the burden of sponsoring the domain without remuneration
from the registrant. A peer-reviewed study, "Risky BIZness: Risks derived from Registrar Name
Management," observed that some registrars have found and utilized a loophole to these
constraints by renaming the host objects that are subordinate to the expiring domain.1 Once
renamed, the host objects are what Akiwate et al.—and subsequently the SSAC—refers to as
sacrificial nameservers.
This report focuses on a specific type of sacrificial nameserver where the parent domains of the renamed host objects are considered to be unsafe because they are registrable. Registrable
parent domains of sacrificial nameservers introduce a new attack surface for domain resolution
hijacking, as malicious actors can exploit unsafe sacrificial nameservers to gain unauthorized
control over the dependent domains, leading to manipulation or disruption. Unlike traditional
domain hijacking techniques that exploit compromised account credentials or manipulate the
resolution protocol, this report focuses on this unforeseen risk arising from a longstanding
practice employed by some registrars.
In this report, the SSAC explores potential solutions to remediate exposed domains and prevent
the creation of new unsafe sacrificial nameservers. The SSAC examines each proposed solution for its feasibility, effectiveness, and potential to reduce the attack surface without introducing undue complexity or new vulnerabilities into the DNS ecosystem.
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Believing Anthropomorphism: Examining the Role of Anthropomorphic Cues on User Trust in Large Language Models
Michelle Cohn
Femi Olanubi
Zion Mengesha
Daniel Padgett
CM (Association of Computing Machinery) CHI conference on Human Factors in Computing Systems 2024 (2024)
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People now regularly interface with Large Language Models (LLMs) via speech and text (e.g., Bard) interfaces. However, little is known about the relationship between how users anthropomorphize an LLM system (i.e., ascribe human-like characteristics to a system) and how they trust the information the system provides. Participants (n=2,165; ranging in age from 18-90 from the United States) completed an online experiment, where they interacted with a pseudo-LLM that varied in modality (text only, speech + text) and grammatical person (“I” vs. “the system”) in its responses. Results showed that the “speech + text” condition led to higher anthropomorphism of the system overall, as well as higher ratings of accuracy of the information the system provides. Additionally, the first-person pronoun (“I”) led to higher information accuracy and reduced risk ratings, but only in one context. We discuss these findings for their implications for the design of responsible, human–generative AI experiences.
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TRINDs: Assessing the Diagnostic Capabilities of Large Language Models for Tropical and Infectious Diseases
Steve Adudans
Oluwatosin Akande
Chintan Ghate
Sylvanus Aitkins
Geoffrey Siwo
Lynda Osadebe
Nenad Tomašev
Eric Ndombi
Preview abstract
Neglected tropical diseases (NTDs) and infectious diseases disproportionately affect the poorest regions of the world. While large language models (LLMs) have shown promise for medical question answering, there is limited work focused on tropical and infectious disease-specific explorations. We introduce TRINDs, a dataset of 52 tropical and infectious diseases with demographic and semantic clinical and consumer augmentations. We evaluate various context and counterfactual locations to understand their influence on LLM performance. Results show that LLMs perform best when provided with contextual information such as demographics, location, and symptoms. We also develop TRINDs-LM, a tool that enables users to enter symptoms and contextual information to receive a most likely diagnosis. In addition to the LLM evaluations, we also conducted a human expert baseline study to assess the accuracy of human experts in diagnosing tropical and infectious diseases with 7 medical and public health experts. This work demonstrates methods for creating and evaluating datasets for testing and optimizing LLMs, and the use of a tool that could improve digital diagnosis and tracking of NTDs.
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In this talk, we will introduce the development and evolution of speaker diarization technologies at Google in the past decade, and how they landed as impactful products such as Cloud Speech-to-Text and the Pixel Recorder app. The talk will cover four critical milestones of the speaker diarization technologies at Google: (1) leveraging deep speaker embeddings; (2) leveraging supervised clustering; (3) leveraging sequence transducers; and (4) leveraging large language models. The talk will also discuss how speaker diarization will evolve in the new era of multimodal large language models.
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Creativity, Generative AI, and Software Development: A Research Agenda
Victoria Jackson
Bogdan Vasilescu
Daniel Russo
Paul Ralph
Maliheh Izadi
Rafael Prikladnicki
Anielle Lisboa
Andre van der Hoek
Preview abstract
Creativity has always been considered a major differentiator to separate the good from the great, and we believe the importance of creativity to software development will only increase as GenAI becomes embedded in developer tool-chains and working practices. This paper uses the McLuhan tetrad alongside scenarios of how GenAI may disrupt software development more broadly, to identify potential impacts GenAI may have on creativity within software development. The impacts are discussed along with a future research agenda comprising of six connected themes that consider how individual capabilities, team capabilities, the product, unintended consequences, society, and human aspects can be affected.
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Federated Variational Inference: Towards Improved Personalization and Generalization
Elahe Vedadi
Josh Dillon
Philip Mansfield
Karan Singhal
Arash Afkanpour
Warren Morningstar
AAAI Federated Learning on the Edge Symposium (2024)
Preview abstract
Conventional federated learning algorithms train a single global model by leveraging all participating clients' data. However, due to heterogeneity in client generative distributions and predictive models, these approaches may not appropriately approximate the predictive process, converge to an optimal state, or generalize to new clients. We study personalization and generalization in stateless cross-device federated learning setups assuming heterogeneity in client data distributions and predictive models. We first propose a hierarchical generative model and formalize it using Bayesian Inference. We then approximate this process using Variational Inference to train our model efficiently. We call this algorithm Federated Variational Inference (FedVI). We use PAC-Bayes analysis to provide generalization bounds for FedVI. We evaluate our model on FEMNIST and CIFAR-100 image classification and show that FedVI beats the state-of-the-art on both tasks.
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A product manager’s specific role varies from one company to the next. Still, all product managers balance many aspects of their job, including customers’ needs, a vision for new products, and the project team. So what tools and strategies are needed to create a successful career as a product manager? What are the “5 Things You Need To Create A Successful Career As A Product Manager”? Authority Magazine speaks with Aqsa Fulara, a product manager at Google to answer these questions with stories and insights from her experiences.
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Generative AI (GAI) is proliferating, and among its many applications are to support creative work (e.g., generating text, images, music) and to enhance accessibility (e.g., captions of images and audio). As GAI evolves, creatives must consider how (or how not) to incorporate these tools into their practices. In this paper, we present interviews at the intersection of these applications. We learned from 10 creatives with disabilities who intentionally use and do not use GAI in and around their creative work. Their mediums ranged from audio engineering to leatherwork, and they collectively experienced a variety of disabilities, from sensory to motor to invisible disabilities. We share cross-cutting themes of their access hacks, how creative practice and access work become entangled, and their perspectives on how GAI should and should not fit into their workflows. In turn, we offer qualities of accessible creativity with responsible AI that can inform future research.
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Expressing and Analyzing Quantum Algorithms with Qualtran
Charles Yuan
Anurudh Peduri
arXiv::2409.04643 (2024)
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Quantum computing's transition from theory to reality has spurred the need for novel software tools to manage the increasing complexity, sophistication, toil, and chance for error of quantum algorithm development. We present Qualtran, an open-source library for representing and analyzing quantum algorithms. Using carefully chosen abstractions and data structures, we can simulate and test algorithms, automatically generate information-rich diagrams, and tabulate resource requirements. Qualtran offers a \emph{standard library} of algorithmic building blocks that are essential for modern cost-minimizing compilations. Its capabilities are showcased through the re-analysis of key algorithms in Hamiltonian simulation, chemistry, and cryptography. The resulting architecture-independent resource counts can be forwarded to our implementation of cost models to estimate physical costs like wall-clock time and number of physical qubits assuming a surface-code architecture. Qualtran provides a foundation for explicit constructions and reproducible analysis, fostering greater collaboration within the quantum algorithm development community. We believe tools like Qualtran will accelerate progress in the field.
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Now You See Me, Now You Don't: 'Poverty of the Stimulus' Problems and Arbitrary Correspondences in End-to-End Speech Models
Proceedings of the Second Workshop on Computation and Written Language (CAWL) 2024
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End-to-end models for speech recognition and speech synthesis have many benefits, but we argue they also face a unique set of challenges not encountered in conventional multi-stage hybrid systems, which relied on the explicit injection of linguistic knowledge through resources such as phonemic dictionaries and verbalization grammars. These challenges include handling words with unusual grapheme-to-phoneme correspondences, converting between written forms like ‘12’ and spoken forms such as ‘twelve’, and contextual disambiguation of homophones or homographs. We describe the mitigation strategies that have been used for these problems in end-to-end systems, either implicitly or explicitly, and call out that the most commonly used mitigation techniques are likely incompatible with newly emerging approaches that use minimal amounts of supervised audio training data. We review best-of-both-world approaches that allow the use of end-to-end models combined with traditional linguistic resources, which we show are increasingly straightforward to create at scale, and close with an optimistic outlook for bringing speech technologies to many more languages by combining these strands of research.
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Conformal Language Modeling
Victor Quach
Adam Fisch
Adam Yala
Jae Ho Sohn
Tommi Jaakkola
Regina Barzilay
ICLR (2024)
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In this paper, we propose a novel approach to conformal prediction (CP) that is adapted to generative, large language models (LLMs). Conformal prediction is a popular technique for deriving prediction sets from machine learning models that have rigorous, statistical performance guarantees. We extend conformal techniques to a broad class of language models that sample from a conditional distribution over the combinatorial, unbounded space of possible text outputs, given some input prompt. Specifically, we translate the process of constructing prediction sets into calibrating a \emph{stopping rule}, under which we draw diverse samples from our model until we are confident that the growing set of candidate answers includes at least one high-quality response. At the same time, we calibrate a \emph{rejection rule} to selectively discard low-quality or redundant responses to reduce sample noise. Under minimal assumptions, we theoretically prove that our resulting output sets contain at least one high-quality answer with some desired probability that a user can set (such as $90\%$), while still remaining empirically precise on average. Furthermore, within this set of sampled candidate answers, we show that we can also accurately identify subsets of individual components (e.g., phrases or sentences) that are each independently correct (e.g., that are not ``hallucinations'')---again, with provably high probability. We demonstrate the effectiveness of our approach on multiple types of large language models applied to tasks in open-domain question answering, text summarization, and radiology report generation.
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The latent space of diffusion model mostly still remains unexplored, despite its great success and potential in the field of generative modeling. In fact, the latent space of existing diffusion models are entangled, with a distorted mapping from its latent space to image space. To tackle this problem, we present Isometric Diffusion, equipping a diffusion model with a geometric regularizer to guide the model to learn a geometrically sound latent space. Our approach allows diffusion models to learn a more disentangled latent space, which enables smoother interpolation, more accurate inversion, and more precise control over attributes directly in the latent space. Extensive experiments illustrate advantages of the proposed method in image interpolation, image inversion, and linear editing.
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A Versatile Diffusion Transformer with Mixture of Noise Levels for Audiovisual Generation
Bradley Kim
Alonso Martinez
Yu-Chuan Su
Agrim Gupta
Lu Jiang
Jacob Walker
Neural Information Processing Systems (NeurIPS) (2024) (to appear)
Preview abstract
Training diffusion models for audiovisual sequences allows for a range of generation tasks by learning conditional distributions of various input-output combinations of the two modalities. Nevertheless, this strategy often requires training a separate model for each task which is expensive. Here, we propose a novel training approach to effectively learn arbitrary conditional distributions in the audiovisual space. Our key contribution lies in how we parameterize the diffusion timestep in the forward diffusion process. Instead of the standard fixed diffusion timestep, we propose applying variable diffusion timesteps across the temporal dimension and across modalities of the inputs. This formulation offers flexibility to introduce variable noise levels for various portions of the input, hence the term mixture of noise levels. We propose a transformer-based audiovisual latent diffusion model and show that it can be trained in a task-agnostic fashion using our approach to enable a variety of audiovisual generation tasks at inference time. Experiments demonstrate the versatility of our method in tackling cross-modal and multimodal interpolation tasks in the audiovisual space. Notably, our proposed approach surpasses baselines in generating temporally and perceptually consistent samples conditioned on the input.
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We describe a quantum algorithm for the Planted Noisy kXOR problem (also known as sparse Learning Parity with Noise) that achieves a nearly quartic (4th power) speedup over the best known classical algorithm while also only using logarithmically many qubits. Our work generalizes and simplifies prior work of Hastings, by building on his quantum algorithm for the Tensor Principal Component Analysis (PCA) problem. We achieve our quantum speedup using a general framework based on the Kikuchi Method (recovering the quartic speedup for Tensor PCA), and we anticipate it will yield similar speedups for further planted inference problems. These speedups rely on the fact that planted inference problems naturally instantiate the Guided Sparse Hamiltonian problem. Since the Planted Noisy kXOR problem has been used as a component of certain cryptographic constructions, our work suggests that some of these are susceptible to super-quadratic quantum attacks.
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