Google Research

The first AI-based mobile application for antibiotic resistance testing

  • Marco Pascucci
  • Guilhem Royer
  • Jakub Adámek
  • David Aristizabal
  • Laetitia Blanche
  • Amine Bezzarga
  • Dominique Boissinot
  • Guillaume Boniface-Chang
  • Alex Brunner
  • Christian Curel
  • Gabriel Dulac-Arnold
  • Nada Malou
  • Clara Nordon
  • Vincent Runge
  • Franck Samson
  • Ellen Marie Sebastian
  • Dena Soukieh
  • Jean-Philippe Vert
  • Christophe Ambroise
  • Mohammed-Amin Madoui
bioRxiv (2020)

Abstract

Antimicrobial resistance is a major global health threat and its development is promoted by antibiotic misuse. While disk diffusion antibiotic susceptibility testing (AST, also called antibiogram) is broadly used to test for antibiotic resistance in bacterial infections, it faces strong criticism because of inter-operator variability and the complexity of interpretative reading. Automatic reading systems address these issues, but are not always adapted or available to resource-limited settings. We present NewAppName, the first artificial intelligence (AI)-based, offline smartphone application for antibiogram analysis. NewAppName captures images with the phone’s camera, and the user is guided throughout the analysis on the same device by a user-friendly graphical interface. An embedded expert system validates the coherence of the antibiogram data and provides interpreted results. The fully automatic measurement procedure of NewAppName’s reading system achieves an overall agreement of 90 % on susceptibility categorization against a hospital-standard automatic system and 98 % against manual measurement (gold standard), with reduced inter-operator variability. NewAppName performance showed that the automatic reading of antibiotic resistance testing is entirely feasible on a smartphone. NewAppName is suited for resource-limited settings, and therefore has the potential to significantly increase patients’ access to AST worldwide.

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